ITPR3

Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.

ITPR3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JRR
Identifiers
Aliases	ITPR3, IP3R, IP3R3, inositol 1,4,5-trisphosphate receptor type 3
External IDs	OMIM: 147267; MGI: 96624; HomoloGene: 1675; GeneCards: ITPR3; OMA:ITPR3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.31 Start 33,620,365 bp End 33,696,574 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 A3.3|17 13.68 cM Start 27,276,278 bp End 27,341,197 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue pylorus skin of arm trigeminal ganglion sural nerve skin of thigh olfactory bulb left lobe of thyroid gland spinal ganglia right lobe of thyroid gland Top expressed in molar pyloric antrum epithelium of stomach skin of external ear mucous cell of stomach lip epithelium of small intestine sciatic nerve rib left colon More reference expression data BioGPS n/a
Gene ontology Molecular function calcium channel activity inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity ion channel activity protein binding inositol 1,3,4,5 tetrakisphosphate binding calcium-release channel activity inositol hexakisphosphate binding inositol 1,4,5 trisphosphate binding calcium ion binding phosphatidylinositol binding Cellular component cytoplasm integral component of membrane endoplasmic reticulum membrane membrane receptor complex plasma membrane apical part of cell integral component of plasma membrane nucleoplasm nucleolus platelet dense tubular network membrane endoplasmic reticulum brush border nucleus nuclear outer membrane myelin sheath soma sarcoplasmic reticulum cytoplasmic vesicle membrane secretory granule membrane Biological process sensory perception of umami taste calcium ion transport into cytosol regulation of cardiac conduction regulation of insulin secretion memory ion transport platelet activation response to calcium ion sensory perception of bitter taste calcium ion transmembrane transport transmembrane transport sensory perception of sweet taste inositol phosphate-mediated signaling calcium ion transport long-term potentiation G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration protein homooligomerization protein heterooligomerization release of sequestered calcium ion into cytosol transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3710 16440 Ensembl ENSG00000096433 ENSMUSG00000042644 UniProt Q14573 P70227 RefSeq (mRNA) NM_002224 NM_080553 RefSeq (protein) NP_002215 NP_542120 Location (UCSC) Chr 6: 33.62 – 33.7 Mb Chr 17: 27.28 – 27.34 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

ITP3 channels serve an important role in the taste transduction pathway of sweet, bitter and umami tastes the gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.

See also

• Inositol trisphosphate receptor

Further reading

• Kline CF, Cunha SR, Lowe JS, et al. (2008). "Revisiting ankyrin-InsP3 receptor interactions: ankyrin-B associates with the cytoplasmic N-terminus of the InsP3 receptor". J. Cell. Biochem. 104 (4): 1244–53. doi:10.1002/jcb.21704. PMC 2858327. PMID 18275062.
• Oishi T, Iida A, Otsubo S, et al. (2008). "A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population". J. Hum. Genet. 53 (2): 151–62. doi:10.1007/s10038-007-0233-3. PMID 18219441.
• Hirose M, Stuyvers B, Dun W, et al. (2008). "Wide long lasting perinuclear Ca²⁺ release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cells". J. Mol. Cell. Cardiol. 45 (2): 176–84. doi:10.1016/j.yjmcc.2008.05.008. PMC 2566512. PMID 18586264.
• Miyachi K, Iwai M, Asada K, et al. (2007). "Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases". Mod Rheumatol. 17 (2): 137–43. doi:10.1007/s10165-006-0555-6. PMID 17437169. S2CID 36516047.
• Tang TS, Guo C, Wang H, et al. (2009). "Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model". J. Neurosci. 29 (5): 1257–66. doi:10.1523/JNEUROSCI.4411-08.2009. PMC 2768402. PMID 19193873.
• Nagaleekar VK, Diehl SA, Juncadella I, et al. (2008). "IP3 receptor-mediated Ca²⁺ release in naive CD4 T cells dictates their cytokine program". J. Immunol. 181 (12): 8315–22. doi:10.4049/jimmunol.181.12.8315. PMC 2756541. PMID 19050248.
• Bandyopadhyay BC, Swaim WD, Liu X, et al. (2005). "Apical localization of a functional TRPC3/TRPC6-Ca²⁺-signaling complex in polarized epithelial cells. Role in apical Ca²⁺ influx". J. Biol. Chem. 280 (13): 12908–16. doi:10.1074/jbc.M410013200. PMID 15623527.
• Kasri NN, Holmes AM, Bultynck G, et al. (2004). "Regulation of InsP3 receptor activity by neuronal Ca²⁺-binding proteins". EMBO J. 23 (2): 312–21. doi:10.1038/sj.emboj.7600037. PMC 1271747. PMID 14685260.
• Hattori M, Suzuki AZ, Higo T, et al. (2004). "Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca²⁺ signaling". J. Biol. Chem. 279 (12): 11967–75. doi:10.1074/jbc.M311456200. PMID 14707143.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Roach JC, Deutsch K, Li S, et al. (2006). "Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden". Am. J. Hum. Genet. 79 (4): 614–27. doi:10.1086/507876. PMC 1592562. PMID 16960798.
• Tojyo Y, Morita T, Nezu A, Tanimura A (2008). "The clustering of inositol 1,4,5-trisphosphate (IP(3)) receptors is triggered by IP(3) binding and facilitated by depletion of the Ca²⁺ store". J. Pharmacol. Sci. 107 (2): 138–50. doi:10.1254/jphs.08021FP. PMID 18544901.
• Singleton PA, Bourguignon LY (2004). "CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca²⁺ signaling leading to nitric oxide production and endothelial cell adhesion and proliferation". Exp. Cell Res. 295 (1): 102–18. doi:10.1016/j.yexcr.2003.12.025. PMID 15051494.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ogasawara H (2008). "The calcium kinetics and inositol trisphosphate receptor properties shape the asymmetric timing window of coincidence detection". J. Neurosci. 28 (17): 4293–4. doi:10.1523/JNEUROSCI.0644-08.2008. PMC 6670947. PMID 18434505.
• Qu HQ, Marchand L, Szymborski A, et al. (2008). "The association between type 1 diabetes and the ITPR3 gene polymorphism due to linkage disequilibrium with HLA class II". Genes Immun. 9 (3): 264–6. doi:10.1038/gene.2008.12. PMID 18340361. S2CID 8563179.
• Wu Z, Bowen WD (2008). "Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells". J. Biol. Chem. 283 (42): 28198–215. doi:10.1074/jbc.M802099200. PMC 2661391. PMID 18539593.
• Martínez-Gámez A, Dent MA (2007). "Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve". NeuroReport. 18 (5): 447–50. doi:10.1097/WNR.0b013e32805868a6. PMID 17496801. S2CID 28136973.
• Garcia-Elias A, Lorenzo IM, Vicente R, Valverde MA (2008). "IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site". J. Biol. Chem. 283 (46): 31284–8. doi:10.1074/jbc.C800184200. PMID 18826956.
• Sundivakkam PC, Kwiatek AM, Sharma TT, et al. (2009). "Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca²⁺ store release-induced Ca²⁺ entry in endothelial cells". Am. J. Physiol., Cell Physiol. 296 (3): C403–13. doi:10.1152/ajpcell.00470.2008. PMC 2660268. PMID 19052258.

External links

• ITPR3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)