ING2

Inhibitor of growth protein 2 is a protein that in humans is encoded by the ING2 gene.

ING2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WES, 2G6Q
Identifiers
Aliases	ING2, ING1L, p33inhibitor of growth family member 2
External IDs	OMIM: 604215; MGI: 1916510; HomoloGene: 20388; GeneCards: ING2; OMA:ING2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q35.1 Start 183,505,058 bp End 183,512,429 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 B1.1 Start 48,120,213 bp End 48,128,591 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid jejunal mucosa right adrenal gland right adrenal cortex buccal mucosa cell left adrenal gland left adrenal cortex gonad palpebral conjunctiva bronchial epithelial cell Top expressed in lens epithelium of lens islet of Langerhans granulocyte epiblast seminiferous tubule renal corpuscle neural layer of retina yolk sac bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding chromatin binding metal ion binding methylated histone binding protein binding phosphatidylinositol binding protein-containing complex binding Cellular component Golgi apparatus plasma membrane Sin3 complex CCAAT-binding factor complex nucleus nucleoplasm cytosol Biological process flagellated sperm motility positive regulation of transforming growth factor beta receptor signaling pathway regulation of transcription, DNA-templated negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of apoptotic signaling pathway male meiosis I transcription, DNA-templated positive regulation of transcription, DNA-templated male germ-line stem cell asymmetric division seminiferous tubule development spermatogenesis spermatid development regulation of growth regulation of response to DNA damage stimulus signal transduction negative regulation of cell population proliferation chromatin organization positive regulation of histone deacetylation regulation of apoptotic process regulation of cellular senescence Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3622 69260 Ensembl ENSG00000168556 ENSMUSG00000063049 UniProt Q9H160 Q9ESK4 RefSeq (mRNA) NM_001291959 NM_001564 NM_023503 RefSeq (protein) NP_001278888 NP_001555 NP_075992 Location (UCSC) Chr 4: 183.51 – 183.51 Mb Chr 8: 48.12 – 48.13 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis.

Further reading

• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Nagashima M, Shiseki M, Miura K, Hagiwara K, Linke SP, Pedeux R, Wang XW, Yokota J, Riabowol K, Harris CC (Aug 2001). "DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53". Proceedings of the National Academy of Sciences of the United States of America. 98 (17): 9671–6. Bibcode:2001PNAS...98.9671N. doi:10.1073/pnas.161151798. PMC 55510. PMID 11481424.
• Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (Feb 2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Molecular and Cellular Biology. 22 (3): 835–48. doi:10.1128/MCB.22.3.835-848.2002. PMC 133546. PMID 11784859.
• Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, Ferguson CG, Payrastre B, Myszka DG, Cantley LC, Wagner G, Divecha N, Prestwich GD, Yuan J (Jul 2003). "The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor". Cell. 114 (1): 99–111. doi:10.1016/S0092-8674(03)00480-X. PMID 12859901. S2CID 16506650.
• Sironi E, Cerri A, Tomasini D, Sirchia SM, Porta G, Rossella F, Grati FR, Simoni G (Apr 2004). "Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence for the involvement of p33ING2/ING1L and SAP30 genes". Journal of Cutaneous Pathology. 31 (4): 318–22. doi:10.1111/j.0303-6987.2004.0187.x. PMID 15005689. S2CID 2520678.
• Chattopadhyay C, Hawke D, Kobayashi R, Maity SN (2004). "Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro". Nucleic Acids Research. 32 (12): 3632–41. doi:10.1093/nar/gkh692. PMC 484179. PMID 15243141.
• He GH, Helbing CC, Wagner MJ, Sensen CW, Riabowol K (Jan 2005). "Phylogenetic analysis of the ING family of PHD finger proteins". Molecular Biology and Evolution. 22 (1): 104–16. doi:10.1093/molbev/msh256. PMID 15356280.
• Chin MY, Ng KC, Li G (Apr 2005). "The novel tumor suppressor p33ING2 enhances UVB-induced apoptosis in human melanoma cells". Experimental Cell Research. 304 (2): 531–43. doi:10.1016/j.yexcr.2004.11.023. PMID 15748897.
• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (Mar 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Pedeux R, Sengupta S, Shen JC, Demidov ON, Saito S, Onogi H, Kumamoto K, Wincovitch S, Garfield SH, McMenamin M, Nagashima M, Grossman SR, Appella E, Harris CC (Aug 2005). "ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation". Molecular and Cellular Biology. 25 (15): 6639–48. doi:10.1128/MCB.25.15.6639-6648.2005. PMC 1190357. PMID 16024799.
• Okano T, Gemma A, Hosoya Y, Hosomi Y, Nara M, Kokubo Y, Yoshimura A, Shibuya M, Nagashima M, Harris CC, Kudoh S (Mar 2006). "Alterations in novel candidate tumor suppressor genes, ING1 and ING2 in human lung cancer". Oncology Reports. 15 (3): 545–9. doi:10.3892/or.15.3.545. PMID 16465410.
• Wang J, Chin MY, Li G (Feb 2006). "The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation". Cancer Research. 66 (4): 1906–11. doi:10.1158/0008-5472.CAN-05-3444. PMID 16488987.
• Lu F, Dai DL, Martinka M, Ho V, Li G (Jul 2006). "Nuclear ING2 expression is reduced in human cutaneous melanomas". British Journal of Cancer. 95 (1): 80–6. doi:10.1038/sj.bjc.6603205. PMC 2360493. PMID 16755297.
• Wang Y, Wang J, Li G (Jul 2006). "Leucine zipper-like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis". FEBS Letters. 580 (16): 3787–93. Bibcode:2006FEBSL.580.3787W. doi:10.1016/j.febslet.2006.05.065. PMID 16782091. S2CID 40317066.
• Huang W, Zhang H, Davrazou F, Kutateladze TG, Shi X, Gozani O, Prestwich GD (May 2007). "Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling". Journal of the American Chemical Society. 129 (20): 6498–506. doi:10.1021/ja070195b. PMC 2553394. PMID 17469822.

External links

• ING2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.