IGHG3

Ig gamma-3 chain C region is a protein that in humans is encoded by the IGHG3 gene.

IGHG3
Identifiers
Aliases	IGHG3, IgG3, immunoglobulin heavy constant gamma 3 (G3m marker)
External IDs	OMIM: 147120; GeneCards: IGHG3; OMA:IGHG3 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q32.33 Start 105,764,503 bp End 105,771,405 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node spleen bone marrow cells appendix olfactory zone of nasal mucosa upper lobe of left lung tonsil gallbladder left uterine tube right coronary artery n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 3502 n/a Ensembl ENSG00000211897 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 14: 105.76 – 105.77 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Further reading

• Michaelsen TE, Frangione B, Franklin EC (1977). "Primary structure of the "hinge" region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit". J. Biol. Chem. 252 (3): 883–9. doi:10.1016/S0021-9258(19)75181-3. PMID 402363.
• Wolfenstein-Todel C, Frangione B, Prelli F, Franklin EC (1976). "The amino acid sequence of "heavy chain disease" protein ZUC. Structure of the Fc fragment of immunoglobulin G3". Biochem. Biophys. Res. Commun. 71 (4): 907–14. doi:10.1016/0006-291X(76)90741-5. PMID 823945.
• Huck S, Fort P, Crawford DH, et al. (1986). "Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes". Nucleic Acids Res. 14 (4): 1779–89. doi:10.1093/nar/14.4.1779. PMC 339572. PMID 3081877.
• Frangione B, Rosenwasser E, Prelli F, Franklin EC (1980). "Primary structure of human gamma 3 immunoglobulin deletion mutant: gamma 3 heavy-chain disease protein Wis". Biochemistry. 19 (18): 4304–8. doi:10.1021/bi00559a024. PMID 6774747.
• Lewis AP, Lemon SM, Barber KA, et al. (1993). "Rescue, expression, and analysis of a neutralizing human anti-hepatitis A virus monoclonal antibody". J. Immunol. 151 (5): 2829–38. doi:10.4049/jimmunol.151.5.2829. PMID 8395549. S2CID 24962823.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.