HULC (gene)

HULC
Identifiers
Aliases	HULC, HCCAT1, LINC00078, NCRNA00078, hepatocellular carcinoma up-regulated long non-coding RNA
External IDs	OMIM: 612210; GeneCards: HULC; OMA:HULC - orthologs
Orthologs
	728655
	n/a
	ENSG00000251164; ENSG00000276019
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

In molecular biology, Highly Up-regulated in Liver Cancer (non-protein coding), also known as HULC, is a long non-coding RNA. It was first identified in hepatocellular carcinoma, and is also expressed in colorectal carcinomas that metastasise to the liver.^[2]^[3] It may have a role in the post-transcriptional regulation of gene expression.^[2] It downregulates the expression of several microRNAs, including miR-372.^[4] Expression of HULC is upregulated by CREB, there is a CREB-binding site in the promoter of HULC. miR-372 represses translation of the kinase PRKACB, so downregulation of miR-372 leads to increased levels of PRKACB. PRKACB activates CREB by phosphorylation, therefore leading to increased expression of HULC.^[4]

References

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Panzitt K, Tschernatsch MM, Guelly C, Moustafa T, Stradner M, Strohmaier HM, Buck CR, Denk H, Schroeder R, Trauner M, Zatloukal K (Jan 2007). "Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA". Gastroenterology. 132 (1): 330–342. doi:10.1053/j.gastro.2006.08.026. PMID 17241883.
^ Matouk IJ, Abbasi I, Hochberg A, Galun E, Dweik H, Akkawi M (Jun 2009). "Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis". European Journal of Gastroenterology & Hepatology. 21 (6): 688–692. doi:10.1097/meg.0b013e328306a3a2. PMID 19445043. S2CID 39245106.
^ ^a ^b Wang J, Liu X, Wu H, Ni P, Gu Z, Qiao Y, Chen N, Sun F, Fan Q (Sep 2010). "CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer". Nucleic Acids Research. 38 (16): 5366–5383. doi:10.1093/nar/gkq285. PMC 2938198. PMID 20423907.