| |
human major histocompatibility complex, class II, DR9
| |
| Haplotypes groups | DQA*01:DRB1*0901 to
DQA*01:DRB1*0906 |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101
|
| Symbol(s) | HLA-DRA[permanent dead link] |
| EBI-HLA | DRA*0101 |
| Identifiers | beta 1 *0901
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| Symbol(s) | HLA-DRB1[permanent dead link] |
| EBI-HLA | DRB1*0901 Archived 2011-05-15 at the Wayback Machine |
| Shared data | |
| Locus | chr.6 6p21.31 |
HLA-DR09 (DR9) is a HLA-DR serotype that recognizes the DRB1*0901 gene product.
Serology
edit| DRB1* | DR9 | Sample | ||
| allele | % | % | % | size (N) |
| 0901 | 95 | 1058 |
The serological reaction of DR9 is relatively good. The serology of DRB1*0902 to *0906 serotypes is unknown.
Disease associations
editDRB1*0901: Early childhood myasthenia gravis[2]
Extended linkage
editDRB1*0901:DQA1*0301:DQB1*0303 haplotype: Early childhood myastenia gravis[2]
Genetic linkage
editDR09 Haplotypes
| |||
| DRA | DRB1 | ||
|---|---|---|---|
| Haplotypes | *0101 | *0901 | *0101 |
| DQA1 | DQB1 | DRB1 | |
| Haplotypes | *0301 | *0303 | *0901 |
| HLA-A | HLA-B | DRB1 | |
| Haplotypes | *0000 | *0000 | *0901 |
HLA-DR9 is genetically linked to HLA-DR53, and HLA-DQ3 and DQ9 serotypes.
References
edit- ^ derived from IMGT/HLA
- ^ a b Shinomiya N, Nomura Y, Segawa M (2004). "A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan". Clin Immunol. 110 (2): 154–8. doi:10.1016/j.clim.2003.10.004. PMID 15003812.