Histone H2A type 2-C is a protein that in humans is encoded by the HIST2H2AC gene .[ 5] [ 6] [ 7] [ 8]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes . Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer , around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family.[ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000184260 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068855 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Collart D, Romain PL, Huebner K, Pockwinse S, Pilapil S, Cannizzaro LA, Lian JB, Croce CM, Stein JL, Stein GS (Jan 1993). "A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing". J Cell Biochem . 50 (4): 374–85. doi :10.1002/jcb.240500406 . PMID 1469070 . S2CID 7732783 . ^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet . 101 (3): 284–94. doi :10.1007/s004390050630 . PMID 9439656 . S2CID 38539096 . ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics . 80 (5): 487–98. doi :10.1016/S0888-7543(02)96850-3 . PMID 12408966 . ^ a b "Entrez Gene: HIST2H2AC histone cluster 2, H2ac" .
El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter" . Mol. Cell. Biol . 18 (5): 2535–44. doi :10.1128/mcb.18.5.2535 . PMC 110633 PMID 9566873 . Kimura A, Horikoshi M (1999). "Tip60 acetylates six lysines of a specific class in core histones in vitro" . Genes Cells . 3 (12): 789–800. doi :10.1046/j.1365-2443.1998.00229.x PMID 10096020 . Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones" . Virology . 277 (2): 278–95. doi :10.1006/viro.2000.0593 PMID 11080476 . Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA" . Virology . 289 (2): 312–26. doi :10.1006/viro.2001.1129 PMID 11689053 . Chen A, Kleiman FE, Manley JL, et al. (2002). "Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase" . J. Biol. Chem . 277 (24): 22085–92. doi :10.1074/jbc.M201252200 PMID 11927591 . Lahn BT, Tang ZL, Zhou J, et al. (2002). "Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis" . Proc. Natl. Acad. Sci. U.S.A . 99 (13): 8707–12. Bibcode :2002PNAS...99.8707L . doi :10.1073/pnas.082248899 PMC 124363 PMID 12072557 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Yoon HG, Chan DW, Huang ZQ, et al. (2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1" . EMBO J . 22 (6): 1336–46. doi :10.1093/emboj/cdg120 . PMC 151047 PMID 12628926 . Fujita K, Shimazaki N, Ohta Y, et al. (2004). "Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone" . Genes Cells . 8 (6): 559–71. doi :10.1046/j.1365-2443.2003.00656.x PMID 12786946 . S2CID 25223336 . Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter" . EMBO J . 22 (24): 6550–61. doi :10.1093/emboj/cdg631 . PMC 291826 PMID 14657027 . Zhang Y, Griffin K, Mondal N, Parvin JD (2004). "Phosphorylation of histone H2A inhibits transcription on chromatin templates" . J. Biol. Chem . 279 (21): 21866–72. doi :10.1074/jbc.M400099200 PMID 15010469 . Aihara H, Nakagawa T, Yasui K, et al. (2004). "Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo" . Genes Dev . 18 (8): 877–88. doi :10.1101/gad.1184604 . PMC 395847 PMID 15078818 . Wang H, Wang L, Erdjument-Bromage H, et al. (2004). "Role of histone H2A ubiquitination in Polycomb silencing". Nature . 431 (7010): 873–8. Bibcode :2004Natur.431..873W . doi :10.1038/nature02985 . PMID 15386022 . S2CID 4344378 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Braastad CD, Hovhannisyan H, van Wijnen AJ, et al. (2005). "Functional characterization of a human histone gene cluster duplication". Gene . 342 (1): 35–40. doi :10.1016/j.gene.2004.07.036 . PMID 15527963 . Hagiwara T, Hidaka Y, Yamada M (2005). "Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes". Biochemistry . 44 (15): 5827–34. doi :10.1021/bi047505c . PMID 15823041 . Bonenfant D, Coulot M, Towbin H, et al. (2006). "Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry" . Mol. Cell. Proteomics . 5 (3): 541–52. doi :10.1074/mcp.M500288-MCP200 PMID 16319397 .
