English: The function of TFH cells: A subset of naive T cells in the T cell zone are activated by antigen and migrate to the follicles where they differentiate into TFH cells which interact with and instruct Follicular B (Fo B) cells to undergo isotype switching, somatic hypermutation, and rapid cellular division to seed germinal centers (GC). Within these germinal centers, TFH cells continue to provide help to GC B cells to facilitate their production of high affinity antibody producing plasma cells (PC) and long-lived memory (Mem) B cells.
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