ESX1

Homeobox protein ESX1 is a protein that in humans is encoded by the ESX1 gene.

ESX1
Identifiers
Aliases	ESX1, ESX1L, ESXR1, ESX homeobox 1
External IDs	OMIM: 300154; HomoloGene: 49152; GeneCards: ESX1; OMA:ESX1 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq22.2 Start 104,250,038 bp End 104,254,933 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle right testis left testis gonad epithelium of colon placenta endometrium human musculoskeletal system muscular system skeletal muscle n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus cytoplasm nuclear speck Biological process negative regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated transcription, DNA-templated regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80712 n/a Ensembl ENSG00000123576 n/a UniProt Q8N693 n/a RefSeq (mRNA) NM_153448 n/a RefSeq (protein) NP_703149 n/a Location (UCSC) Chr X: 104.25 – 104.25 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Further reading

• Murthi P, Doherty VL, Said JM, et al. (2006). "Homeobox gene ESX1L expression is decreased in human pre-term idiopathic fetal growth restriction". Mol. Hum. Reprod. 12 (5): 335–40. doi:10.1093/molehr/gal037. PMID 16613891.
• Figueiredo AL, Salles MG, Albano RM, Porto LC (2005). "Molecular and morphologic analyses of expression of ESX1L in different stages of human placental development". J. Cell. Mol. Med. 8 (4): 545–50. doi:10.1111/j.1582-4934.2004.tb00479.x. PMC 6740265. PMID 15601583.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ozawa H, Ashizawa S, Naito M, et al. (2004). "Paired-like homeodomain protein ESXR1 possesses a cleavable C-terminal region that inhibits cyclin degradation". Oncogene. 23 (39): 6590–602. doi:10.1038/sj.onc.1207884. PMID 15235584.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.