EGR3

Early growth response protein 3 is a protein in humans, encoded by the EGR3 gene.

EGR3
Identifiers
Aliases	EGR3, EGR-3, PILOT, early growth response 3
External IDs	OMIM: 602419; MGI: 1306780; HomoloGene: 37923; GeneCards: EGR3; OMA:EGR3 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8p21.3 Start 22,687,659 bp End 22,693,480 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 D2 Start 70,314,652 bp End 70,320,063 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh parietal pleura gastric mucosa mucosa of paranasal sinus lactiferous duct skin of arm sural nerve orbitofrontal cortex frontal pole periodontal fiber Top expressed in prefrontal cortex hair follicle primary motor cortex skin of abdomen olfactory tubercle skin of external ear cingulate gyrus nucleus accumbens piriform cortex Temporal Lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity metal ion binding DNA binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding Cellular component nucleus Biological process circadian rhythm endothelial cell chemotaxis cell migration involved in sprouting angiogenesis muscle organ development regulation of transcription, DNA-templated positive regulation of endothelial cell proliferation cellular response to fibroblast growth factor stimulus negative regulation of apoptotic process cellular response to vascular endothelial growth factor stimulus transcription, DNA-templated neuromuscular synaptic transmission peripheral nervous system development positive regulation of T cell differentiation in thymus regulation of gamma-delta T cell differentiation positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II cellular response to growth factor stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1960 13655 Ensembl ENSG00000179388 ENSMUSG00000033730 UniProt Q06889 P43300 RefSeq (mRNA) NM_001199880 NM_001199881 NM_004430 NM_001289925 NM_001289927 NM_018781 RefSeq (protein) NP_001186809 NP_001186810 NP_004421 NP_001276854 NP_001276856 NP_061251 Location (UCSC) Chr 8: 22.69 – 22.69 Mb Chr 14: 70.31 – 70.32 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controlling biological rhythm. It may also play a role in muscle development.

Further reading

• Yamada K, Gerber DJ, Iwayama Y, et al. (2007). "Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 104 (8): 2815–2820. doi:10.1073/pnas.0610765104. PMC 1815264. PMID 17360599.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yoo YG, Lee MO (2004). "Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor". J. Biol. Chem. 279 (35): 36242–36249. doi:10.1074/jbc.M401290200. PMID 15173177.
• Inoue A, Omoto Y, Yamaguchi Y, et al. (2005). "Transcription factor EGR3 is involved in the estrogen-signaling pathway in breast cancer cells". J. Mol. Endocrinol. 32 (3): 649–661. doi:10.1677/jme.0.0320649. PMID 15171706.
• Liu D, Jia H, Holmes DI, et al. (2004). "Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1". Arterioscler. Thromb. Vasc. Biol. 23 (11): 2002–2007. doi:10.1161/01.ATV.0000098644.03153.6F. PMID 14525795.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tourtellotte WG, Milbrandt J (1998). "Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3". Nat. Genet. 20 (1): 87–91. doi:10.1038/1757. PMID 9731539. S2CID 5707748.
• Morris ME, Viswanathan N, Kuhlman S, et al. (1998). "A screen for genes induced in the suprachiasmatic nucleus by light". Science. 279 (5356): 1544–1547. Bibcode:1998Sci...279.1544M. doi:10.1126/science.279.5356.1544. PMID 9488654.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–828. doi:10.1101/gr.6.9.807. PMID 8889549.
• Mages HW, Stamminger T, Rilke O, et al. (1993). "Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells". Int. Immunol. 5 (1): 63–70. doi:10.1093/intimm/5.1.63. PMID 8443122.

External links

• EGR3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.