Dibunate

Dibunate
Clinical data
Trade names	Aducin, Becantal, Becantex, Bechisan, Bexedyl, Keuten, Linctussal, Pectoro
ATC code	R05DB16 (WHO) ;
Identifiers
	IUPAC name 2,6-Di-tert-butylnaphthalene-1-sulfonic acid;
CAS Number	14992-58-6;
PubChem CID	84746;
DrugBank	DB13796 ;
ChemSpider	76450 ;
UNII	ZXY319VL5S;
KEGG	D01700;
ChEBI	CHEBI:145567;
ChEMBL	ChEMBL1865134;
CompTox Dashboard (EPA)	DTXSID7048245 ;
ECHA InfoCard	100.035.511
Chemical and physical data
Formula	C18H24O3S
Molar mass	320.45 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=S(=O)(O)c1c2c(ccc1C(C)(C)C)cc(cc2)C(C)(C)C;
	InChI InChI=1S/C18H24O3S/c1-17(2,3)13-8-9-14-12(11-13)7-10-15(18(4,5)6)16(14)22(19,20)21/h7-11H,1-6H3,(H,19,20,21) ; Key:WBEBQCINXJDZCX-UHFFFAOYSA-N ;
	(verify)

Dibunate is a cough suppressant.^[1] As the sodium salt, it has been marketed under the name Becantyl (in the United Kingdom), Becantex (in continental Europe), or Linctussal with a dosage of 20 to 30 mg, as either syrup or tablets.^[2]

Similar to benzonatate, it is a peripherally acting drug. It has not been reported to cause sedation, euphoria, habituation, or respiratory depression, unlike narcotic antitussives such as codeine. It may work by blocking afferent signals in the reflex arc which controls cough.^[3] Nausea is rarely seen as an adverse effect.^[4]

References

^ Sevelius H, Colmore JP (1967). "Antitussive effect of ethyl dibunate in patients with chronic cough". Clinical Pharmacology and Therapeutics. 8 (3): 381–4. doi:10.1002/cpt196783381. PMID 5338382.
^ "To-day's drugs: Cough suppressants". Br Med J. 1 (5391): 1165-1167. May 2, 1964. PMC 1813498. PMID 14120813.
^ Simon SW (1957). "A comparative study of two new non-narcotic antitussive drugs". Ohio State Med J. 53 (12): 1426-7. PMID 13493953.
^ Schlesser JL (1991). Drugs Available Abroad, 1st Edition. Derwent Publications Ltd. p. 63. ISBN 0-8103-7177-4.

This drug article relating to the respiratory system is a stub. You can help Wikipedia by expanding it.

[1] Sevelius H, Colmore JP (1967). "Antitussive effect of ethyl dibunate in patients with chronic cough". Clinical Pharmacology and Therapeutics. 8 (3): 381–4. doi:10.1002/cpt196783381. PMID 5338382.

[2] "To-day's drugs: Cough suppressants". Br Med J. 1 (5391): 1165-1167. May 2, 1964. PMC 1813498. PMID 14120813.

[3] Simon SW (1957). "A comparative study of two new non-narcotic antitussive drugs". Ohio State Med J. 53 (12): 1426-7. PMID 13493953.

[4] Schlesser JL (1991). Drugs Available Abroad, 1st Edition. Derwent Publications Ltd. p. 63. ISBN 0-8103-7177-4.

[1]

[2]

[3]

[4]