COMMD1

COMM domain-containing protein 1 is a protein that is encoded by the COMMD1 gene in humans. It was originally regarded as Murr1 before being differentiated and renamed by Dr. Ezra Burstein's Lab

COMMD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2H2M
Identifiers
Aliases	COMMD1, C2orf5, MURR1, copper metabolism domain containing 1
External IDs	OMIM: 607238; MGI: 109474; HomoloGene: 17604; GeneCards: COMMD1; OMA:COMMD1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p15 Start 61,888,724 bp End 62,147,247 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 A3.2|11 14.22 cM Start 22,846,136 bp End 22,932,382 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle tibialis anterior muscle cardiac muscle tissue of right atrium right ventricle deltoid muscle Skeletal muscle tissue of biceps brachii right auricle vena cava skin of arm mucosa of ileum Top expressed in embryo embryo spermatocyte right kidney ventricular zone external carotid artery intercostal muscle epiblast medullary collecting duct internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity phosphatidylinositol-3,5-bisphosphate binding metal ion binding phosphatidylinositol-3,4-bisphosphate binding phosphatidic acid binding protein binding identical protein binding phosphatidylinositol-4,5-bisphosphate binding copper ion binding phosphatidylinositol-3,4,5-trisphosphate binding lipid binding Cellular component cytoplasm recycling endosome endosome membrane Cul2-RING ubiquitin ligase complex early endosome endosome membrane cytoplasmic vesicle nucleus nucleoplasm cytosol Biological process negative regulation of sodium ion transmembrane transport regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of protein localization to cell surface plasma membrane to endosome transport regulation of proteasomal ubiquitin-dependent protein catabolic process protein transport negative regulation of NF-kappaB transcription factor activity positive regulation of protein ubiquitination Golgi to plasma membrane transport post-translational protein modification copper ion homeostasis protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 150684 17846 Ensembl ENSG00000173163 ENSMUSG00000051355 UniProt Q8N668 Q8K4M5 RefSeq (mRNA) NM_152516 NM_001321781 NM_001321782 NM_001371765 NM_144514 NM_001361661 RefSeq (protein) NP_001308710 NP_001308711 NP_689729 NP_001358694 NP_653097 NP_001348590 Location (UCSC) Chr 2: 61.89 – 62.15 Mb Chr 11: 22.85 – 22.93 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

External links

• Human COMMD1 genome location and COMMD1 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Müller T, van de Sluis B, Zhernakova A, et al. (2003). "The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis". J. Hepatol. 38 (2): 164–8. doi:10.1016/S0168-8278(02)00356-2. PMID 12547404.
• Tao TY, Liu F, Klomp L, et al. (2004). "The copper toxicosis gene product Murr1 directly interacts with the Wilson disease protein". J. Biol. Chem. 278 (43): 41593–6. doi:10.1074/jbc.C300391200. PMID 12968035.
• Klomp AE, van de Sluis B, Klomp LW, Wijmenga C (2004). "The ubiquitously expressed MURR1 protein is absent in canine copper toxicosis". J. Hepatol. 39 (5): 703–9. doi:10.1016/S0168-8278(03)00380-5. PMID 14568250.
• Biasio W, Chang T, McIntosh CJ, McDonald FJ (2004). "Identification of Murr1 as a regulator of the human delta epithelial sodium channel". J. Biol. Chem. 279 (7): 5429–34. doi:10.1074/jbc.M311155200. PMID 14645214.
• Ganesh L, Burstein E, Guha-Niyogi A, et al. (2004). "The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes". Nature. 426 (6968): 853–7. doi:10.1038/nature02171. hdl:2027.42/62709. PMID 14685242. S2CID 4344050.
• Burstein E, Ganesh L, Dick RD, et al. (2004). "A novel role for XIAP in copper homeostasis through regulation of MURR1". EMBO J. 23 (1): 244–54. doi:10.1038/sj.emboj.7600031. PMC 1271669. PMID 14685266.
• Stuehler B, Reichert J, Stremmel W, Schaefer M (2005). "Analysis of the human homologue of the canine copper toxicosis gene MURR1 in Wilson disease patients". J. Mol. Med. 82 (9): 629–34. doi:10.1007/s00109-004-0557-9. PMID 15205742. S2CID 8184776.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Burstein E, Hoberg JE, Wilkinson AS, et al. (2005). "COMMD proteins, a novel family of structural and functional homologs of MURR1". J. Biol. Chem. 280 (23): 22222–32. doi:10.1074/jbc.M501928200. PMID 15799966.
• Coronado VA, Bonneville JA, Nazer H, et al. (2006). "COMMD1 (MURR1) as a candidate in patients with copper storage disease of undefined etiology". Clin. Genet. 68 (6): 548–51. doi:10.1111/j.1399-0004.2005.00524.x. PMID 16283886. S2CID 27815621.
• Zhang Z, Joh K, Yatsuki H, et al. (2006). "Comparative analyses of genomic imprinting and CpG island-methylation in mouse Murr1 and human MURR1 loci revealed a putative imprinting control region in mice". Gene. 366 (1): 77–86. doi:10.1016/j.gene.2005.08.020. PMID 16305817.
• de Bie P, van de Sluis B, Burstein E, et al. (2006). "Characterization of COMMD protein-protein interactions in NF-kappaB signalling". Biochem. J. 398 (1): 63–71. doi:10.1042/BJ20051664. PMC 1525016. PMID 16573520.
• Sommerhalter M, Zhang Y, Rosenzweig AC (2007). "Solution structure of the COMMD1 N-terminal domain". J. Mol. Biol. 365 (3): 715–21. doi:10.1016/j.jmb.2006.10.030. PMC 2706016. PMID 17097678.
• Maine GN, Mao X, Komarck CM, Burstein E (2007). "COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase". EMBO J. 26 (2): 436–47. doi:10.1038/sj.emboj.7601489. PMC 1783443. PMID 17183367.