CLDN15

Claudin-15 is a protein that in humans is encoded by the CLDN15 gene. It belongs to the group of claudins. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Tight junction. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN10.

CLDN15
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4P79
Identifiers
Aliases	CLDN15, claudin 15
External IDs	OMIM: 615778; MGI: 1913103; HomoloGene: 8646; GeneCards: CLDN15; OMA:CLDN15 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q22.1 Start 101,232,092 bp End 101,238,820 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 G2 Start 136,995,470 bp End 137,004,712 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa duodenum mucosa of ileum germinal epithelium mucosa of transverse colon granulocyte parietal pleura right lobe of liver left uterine tube spleen Top expressed in duodenum crypt of lieberkuhn of small intestine intestinal villus granulocyte jejunum Paneth cell epithelium of small intestine ileum left colon oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function structural molecule activity identical protein binding Cellular component integral component of membrane cell junction plasma membrane lateral plasma membrane membrane bicellular tight junction Biological process calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 24146 60363 Ensembl ENSG00000106404 ENSMUSG00000001739 UniProt P56746 Q9Z0S5 RefSeq (mRNA) NM_138429 NM_001185080 NM_014343 NM_021719 RefSeq (protein) NP_001172009 NP_055158 NP_068365 Location (UCSC) Chr 7: 101.23 – 101.24 Mb Chr 5: 137 – 137 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

External links

• Human CLDN15 genome location and CLDN15 gene details page in the UCSC Genome Browser.

Further reading

• Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502. S2CID 26473781.
• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.
• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
• Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
• Yi X, Wang Y, Yu FS (2000). "Corneal epithelial tight junctions and their response to lipopolysaccharide challenge". Invest. Ophthalmol. Vis. Sci. 41 (13): 4093–100. PMID 11095601.
• Kiuchi-Saishin Y, Gotoh S, Furuse M, et al. (2002). "Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments". J. Am. Soc. Nephrol. 13 (4): 875–86. doi:10.1681/ASN.V134875. PMID 11912246.
• Colegio OR, Van Itallie CM, McCrea HJ, et al. (2002). "Claudins create charge-selective channels in the paracellular pathway between epithelial cells" (PDF). Am. J. Physiol., Cell Physiol. 283 (1): C142–7. doi:10.1152/ajpcell.00038.2002. PMID 12055082. S2CID 9555118.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Van Itallie CM, Fanning AS, Anderson JM (2003). "Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins". Am. J. Physiol. Renal Physiol. 285 (6): F1078–84. doi:10.1152/ajprenal.00116.2003. PMID 13129853.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.