CIAPIN1

CIAPIN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LD4, 2YUI, 4M7R
Identifiers
Aliases	CIAPIN1, 2810413N20Rik, Anamorsin, DRE2, PRO0915, cytokine induced apoptosis inhibitor 1, CIAE2
External IDs	OMIM: 608943; MGI: 1922083; HomoloGene: 10658; GeneCards: CIAPIN1; OMA:CIAPIN1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	57,447,420 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	95,564,986 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; left testis; ; right testis; ; sperm; ; mucosa of transverse colon; ; right adrenal cortex; ; embryo; ; apex of heart; ; ganglionic eminence;
	Top expressed in
	otic placode; ; saccule; ; spermatocyte; ; spermatid; ; yolk sac; ; primitive streak; ; facial motor nucleus; ; fetal liver hematopoietic progenitor cell; ; neural tube; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	methyltransferase activity; iron-sulfur cluster binding; protein binding; metal ion binding; 2 iron, 2 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; electron transfer activity;
Cellular component	cytoplasm; mitochondrial intermembrane space; nucleolus; nucleus; nucleoplasm; mitochondrion;
Biological process	methylation; metabolism; negative regulation of apoptotic process; iron-sulfur cluster assembly; apoptotic process; hemopoiesis; electron transport chain;
	Sources:Amigo / QuickGO
Orthologs
	57019
	109006
	ENSG00000005194
	ENSMUSG00000031781
	Q6FI81
	Q8WTY4
	NM_001308347; NM_001308358; NM_020313
	NM_134141
	NP_001295276; NP_001295287; NP_064709
	NP_598902
	Wikidata
View/Edit Human	View/Edit Mouse

Anamorsin is a protein that in humans is encoded by the CIAPIN1 gene.^[5]^[6]^[7]

CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004).[supplied by OMIM]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000005194 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031781 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Nov 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
^ ^a ^b "Entrez Gene: CIAPIN1 cytokine induced apoptosis inhibitor 1".

External links

Human CIAPIN1 genome location and CIAPIN1 gene details page in the UCSC Genome Browser.

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shibayama H, Takai E, Matsumura I, et al. (2004). "Identification of a Cytokine-induced Antiapoptotic Molecule Anamorsin Essential for Definitive Hematopoiesis". J. Exp. Med. 199 (4): 581–92. doi:10.1084/jem.20031858. PMC 2211823. PMID 14970183.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Hao Z, Li X, Qiao T, et al. (2006). "CIAPIN1 confers multidrug resistance by upregulating the expression of MDR-1 and MRP-1 in gastric cancer cells". Cancer Biol. Ther. 5 (3): 261–6. doi:10.4161/cbt.5.3.2381. PMID 16410721.
Hao Z, Li X, Qiao T, et al. (2007). "Subcellular localization of CIAPIN1". J. Histochem. Cytochem. 54 (12): 1437–44. doi:10.1369/jhc.6A6960.2006. PMC 3958118. PMID 16957168.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000005194 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031781 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10493829-5] Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Nov 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.

[pmid11230166-6] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[entrez-7] "Entrez Gene: CIAPIN1 cytokine induced apoptosis inhibitor 1".

[5]

[6]

[7]

[1]

[2]

[3]

[4]

CIAPIN1

References

External links

Further reading