Wikipedia

Brent Stockwell

Brent Roark Stockwell is an American chemical biologist. He is a Professor of Biological Sciences and Chemistry at Columbia University. In 2012, Stockwell and Scott Dixon coined the term ferroptosis and described several of its key features.

Brent Stockwell
Born
Bay Terrace, Queens, New York, US
Known fordiscovering Ferroptosis
Spouse
Melissa Stockwell
​
(m. 2000)​
AwardsBeckman Young Investigators Award
Academic background
EducationAB, chemistry and economics, Cornell University
PhD, 1999, Harvard University
ThesisForward and reverse chemical genetic studies of transforming growth factor beta signaling (1999)
Academic work
InstitutionsColumbia University
Whitehead Institute
Harvard University
Websitestockwelllab.org

Early life and education

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Stockwell was born in Bay Terrace, New York and attended Hunter College High School. He received his undergraduate degree in chemistry and economics from Cornell University and his Ph.D. in chemistry at Harvard University.[1] While completing his doctorate degree, Stockwell worked in the laboratory of Stuart Schreiber where he spent eighteen months unsuccessfully investigating a molecule that could shut down the protein TGF-beta. He eventually used naturally occurring molecules to block the effects of TGF-beta, resulting in the discovery that synthetic molecules were unlikely to be successful drug candidates.[2] As a result of his research, Stockwell founded CombinatoRx to develop combinations of FDA-approved drugs to fight disease.[3]

Following his PhD, Stockwell was appointed as a Whitehead Fellow at the Whitehead Institute, where he worked on synthetic lethal screens and cell death. In 2003, he developed the first library of biologically annotated compounds and approved drugs to capture the information underlying cellular mechanisms to give scientists greater and more immediate insight into cell biology mechanisms.[4][5] He also began a campaign to identify compounds that selectively kill engineered tumor cells, identifying and naming the novel compound erastin.[6]

Career

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Upon completing his fellowship, Stockwell joined the faculty at Columbia University as an assistant professor of biological sciences and of chemistry. Early into his tenure at the institution, Stockwell found two new compounds, RSL3 and RSL5, that could kill tumor cells.[7] In order to find drug candidates that could selectively kill tumor cells, Stockwell used cells engineered with a cancer-causing mutation and identical cells lacking the mutation.[3] As a result of his research into undiscovered mechanisms controlling cell death, Stockwell received a 2007 Beckman Young Investigators Award[8] and was named a 2009 Howard Hughes Medical Institute Early Career Scientist.[3] Following this, he was one of six winners of the BioAccelerate NYC Prize to conduct late-stage, "proof-of-concept" research on a new class of drugs to treat cancer in a more selective and non-toxic way.[9]

In 2011, Stockwell published his first book entitled The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicine.[10][11] Later, using erastin, Stockwell discovered the process of ferroptosis, coined the term ferroptosis, described its key mechanisms, and developed the first chemical probes to control ferroptosis.[12] In 2014, he received one of 10 recipients of the 2014 Lenfest Distinguished Teaching Awards.[13]

During the COVID-19 pandemic, Stockwell co-published Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors through the journal Nature Communications.[14] He was also recognized by City & State as one of the inaugural Life Sciences Power 50 amongst scientists, entrepreneurs and investors.[15] Later in November, Stockwell was again listed by Clarivate as one of the Highly Cited Researchers of the Year.[16]

In 2023, Stockwell was elected to the National Academy of Medicine.[17]

Selected publications

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  • The Quest for the Cure: The Science and Stories Behind the Next Generation of Medicine (2011)

Personal life

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Stockwell is married to Melissa, an Associate Professor of Pediatrics and Population and Family Health at Columbia.[18] Stockwell has two sons.[19]

References

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  1. ^ "Brent R. Stockwell, Ph.D." columbia.edu. Retrieved November 15, 2020.
  2. ^ Quenqua, Douglas (Winter 2011). "The Long Shot". Columbia University. Retrieved February 21, 2022.
  3. ^ a b c "The 2009 Early Career Scientists: R-T". Howard Hughes Medical Institute. 2009. Retrieved February 21, 2022.
  4. ^ Cameron, David (September 4, 2003). "New Compound Library to Speed Drug Discovery". Whitehead Institute. Retrieved February 21, 2022.
  5. ^ Root, David E.; Flaherty, Stephen P.; Kelley, Brian P.; Stockwell, Brent R. (September 2003). "Biological Mechanism Profiling Using an Annotated Compound Library". Chemistry & Biology. 10 (9): 881–892. doi:10.1016/j.chembiol.2003.08.009. PMID 14522058.
  6. ^ Dolma, Sonam; Lessnick, Stephen L.; Hahn, William C.; Stockwell, Brent R. (March 2003). "Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells". Cancer Cell. 3 (3): 285–296. doi:10.1016/s1535-6108(03)00050-3. PMID 12676586.
  7. ^ "Scientists Discover New Way of Selectively Killing Cancer Cells". Phys.org. March 26, 2008. Retrieved February 21, 2022.
  8. ^ "Beckman Young Investigator Award". Chemical & Engineering News. August 20, 2007. Retrieved February 21, 2022.
  9. ^ "Partnership For New York City And New York City Economic Development Corporation Announce Winners Of $1.5 Million BioAccelerate". Fierce Biotech. May 4, 2010. Retrieved February 21, 2022.
  10. ^ Nathan, David G. (December 2011). "On Discovering Drugs". Harvard Magazine. Retrieved February 21, 2022.
  11. ^ Kroll, David (March 22, 2012). "The valiant interrogator". Nature Chemistry. 4 (239): 239. Bibcode:2012NatCh...4..239K. doi:10.1038/nchem.1316.
  12. ^ Dixon, Scott J. (May 25, 2012). "Ferroptosis: an iron-dependent form of nonapoptotic cell death". Cell. 149 (5): 1060–1072. doi:10.1016/j.cell.2012.03.042. PMC 3367386. PMID 22632970. S2CID 206559990.
  13. ^ "Brent Stockwell Receives 2014 Lenfest Distinguished Teaching Award". Columbia University. March 25, 2014. Retrieved February 21, 2022.
  14. ^ "Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors". Nature Communications. 12 (2016). April 1, 2021. Retrieved February 21, 2022.
  15. ^ "The Life Sciences Power 50". City & State. August 1, 2021. Retrieved February 21, 2022.
  16. ^ "Cancer Center Members Named as Highly Cited Researchers". Columbia University. November 16, 2021. Retrieved February 21, 2022.
  17. ^ "National Academy of Medicine Elects 100 New Members". National Academy of Medicine. Oct 9, 2023.
  18. ^ "Instructional Innovators Brent and Melissa Stockwell Highlighted in Columbia News". Columbia University. September 1, 2015. Retrieved February 21, 2022.
  19. ^ Stockwell, Brent R. (2011). The quest for the cure: the science and stories behind the next generation of medicines. New York: Columbia University Press. ISBN 978-0-231-15212-9.
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Brent Stockwell publications indexed by Google Scholar

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