Wikipedia

Alysson Muotri

Alysson Renato Muotri is a Brazilian researcher from the University of California (UCSD), United States, where he has been working since 2008. He is also the director of the Stem-Cell Program of the UCSD.[3] He's research is about the frontier themes on genetics and neuroscience, like the development of the human nervous system using brain organoids developed from stem cells.[4][5] He is currently the Brazilian biologist with the largest number of high impact scientific publications.[6]

Alysson Muotri
Alma mater
EmployersUniversity of California in San Diego
StatusIn training[2]
Occupationbiologist
Space career
Commercial astronaut
Selection2023[1]
Scientific career
FieldsGenetics, neurosciences
ThesisModulação da expressão do gene de reparo de DNA XPA por meio de vetores genéticos em células humanas (2001)
Doctoral advisorCarlos Frederico Martins Menck
Websitemuotri.ucsd.edu

Biography

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Muotri has a degree in biological sciences from the State University of Campinas (Unicamp) and a PhD in genetic biology from the University of São Paulo (USP). He has experience in genetics, with an emphasis on human and medical genetics, working mainly on the following subjects: DNA repair, viral vectors, cancer, autism, gene therapy and gene modulation. He was one of the first researchers to cultivate embryonic stem cells.[7][8][9][10]

From the beginning of his academic life, Muotri was interested in studying neuroscience. Reading scientific articles led him to learn about the research carried out at the Salk Institute, especially Dr. Fred Gage's line of work, which combines stem cells with the development of new neural networks.[11]

During his post-doctoral studies at the Salk Research Institute, also in San Diego, California, Muotri was a pioneer in showing, in 2005, that human neurons derived from embryonic stem cells were capable of differentiating and functionally integrating into the brains of chimeric animals (made up of cells from two different species).[12][13] Also in 2005, in sophisticated neurogenetic work, he revealed the activity of "jumping genes" (retrotransposable L1 elements) in neural genomes, showing that the brain is made up of a mosaic of neuronal genomes.[14][15] The research changed the then dogma of biology, which suggested that all cells in the body shared the same genome.[16][17]

Using cellular reprogramming (developed by Nobel laureate Shinya Yamanaka[18]), in 2010 he managed to reverse morphological and functional alterations in neurons derived from individuals with autism[19] in the laboratory,[20] opening up prospects for the development of more efficient drugs for Autism Spectrum Disorder.[21][22][23][24][25]

In 2016, he created a cellular model to study Williams Syndrome, opening up the possibility of investigating the cellular and molecular bases of the human social brain.[26][27][28][29] Also in 2016, Muotri led, together with international collaborators, a study showing the causal relationship between the Zika virus circulating in Brazil and cases of microcephaly and birth defects.[30][31][32] In 2018, he developed "mini Neanderthal brains", making it possible to create a new area of science, "neuroarchaeology".[33][34]

In February 2014, he launched the book "Simples assim: células tronco", co-authored with the doctor Adelson Alves, published by Atheneu, with a cover illustrated by the cartoonist Ziraldo.[35][36][37][38]

In April 2016, Muotri, together with other scientists, founded Tismoo [pt], the world's first personalized medicine startup focused on autism and related syndromes,[39][40][41][42] with headquarters in São Paulo and two offices in the United States, in San Diego and Miami.[43]

In May 2016, Tismoo was the first startup to publish a paper in Nature,[44][45][46] having its research recognized in one of the world's most respected scientific journals.[47][48][49] The paper is about the Zika virus and its relationship with the high rate of microcephaly in Brazil. Through its mini-brain technology,[50] the Brazilian startup helped to demonstrate the relationship between the Brazilian version of the virus and how it acts to cause malformation of the cortex and leads to this neurological condition.[51][52][53][54]

In December 2016, he launched the book "Espiral - Conversas Científicas do Século XXI" (Spiral - Scientific Conversations of the 21st Century), published by Atheneu, a collection of more than 200 articles published over ten years as a columnist for G1.[55][56]

In December 2017, the Brazilian researcher discovered in an experiment with mini-brains that a drug used for 60 years against malaria, chloroquine, works as a vaccine against Zika.[57][58][59][60][61]

Then, also using mini-brains, in a study published in January 2018 in the journal Scientific Reports,[62] from the prestigious Nature group, Muotri's team says that the drug Sofosbuvir, used to treat hepatitis C, can cure Zika infection, as well as preventing the transmission of the virus from mother to baby during pregnancy.[63]

On July 25, 2019, Muotri sent to the International Space Station (ISS), in a SpaceX capsule, an autonomous box with dozens of mini-brains, which remained in space for a month. The research aimed to verify the reaction of organoids in microgravity, for research into autism, Alzheimer's disease and other neurological conditions.[64][65][66][67] And he sent the second part of this research, on December 6, 2020, to the ISS.[68][69]

In a study published on December 8, 2020, in the scientific journal EMBO Molecular Medicine, Muotri and his team identified two candidate drugs to neutralize the deficits caused by the lack of the MECP2 gene, which causes Rett syndrome, with laboratory tests carried out on human mini-brains at the University of California at San Diego (USA). Two drugs were used which can now begin phase three clinical trials (already approved in phases 1 and 2, proving they are safe for human consumption). The mini-brains "treated" in Muotri's laboratory began to behave as if they didn't have Rett syndrome.[70]

In 2023, his name was attributed for a mission to the International Space Station, originally in November 2024, to research brain organoids.[71][72][73] He will stay in space for about 10 days and its expedition will be financed by the University of California.[1] Muotri will also select experiments by Brazilian scientists to carry on his flight.[74] At the end of 2023, Muotri revealed that there is interest from Canada and South Korea in investing in the flight, but it is unclear whether the Brazilian government will have any involvement, and that biomedical researcher Livia Luz should be trained as his backup.[75] In an article on May 1, 2024, it was stated that the flight had been postponed until 2025.[76]

Controversies

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Muotri has come to be considered, in some contexts, a controversial figure on the autism scene. Some autistic activists from the autistic rights movement disagree with his statements about curing autism and how he approaches the disorder in his public pronouncements.[77] Alysson, for his part, was asked in an interview with G1 in 2013: “You often face criticism of your work. I've even seen people using pejorative terms with the aim of denigrating your image and making a mockery of all the knowledge you've accumulated. And more than that: not only accumulated, but also shared in an accessible way. Why don't you give up?” Muotri replied: “I' m not giving up, because this kind of criticism doesn't bother me. It's not these critics who pay my salary. Those who do pay think exactly the opposite. If this situation ever reverses, I think I'll give up science and become a second-class pseudo-celebrity.”[78][79]

Works

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  • Simples assim: células tronco. São Paulo: Atheneu. 2014. ISBN 9788538804765.
  • Espiral — Conversas Científicas do Século XXI. São Paulo: Atheneu. 2016. ISBN 9788538807667.

Awards

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  • 2002: Pew Latin America Postdoctoral Fellowship, La Jolla, California[80]
  • 2009: NIH Director's New Innovator Award[81]
  • 2011: PopTech Science and Public Leadership Fellow[82]
  • 2013: EUREKA (Exceptional, Unconventional Research Enabling Knowledge Acceleration) NIMH Award[83]
  • 2014: NARSAD Independent Investigator Award[84]

See also

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References

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  1. ^ a b "1º cientista brasileiro escalado para ir ao espaço conduzirá estudo que pode mudar a colonização interplanetária". G1 (in Brazilian Portuguese). 2023-07-01. Retrieved 2023-10-02.
  2. ^ "Autismo e minicérebros: as pesquisas do cientista brasileiro que quer ir para a estação espacial". Estadão (in Brazilian Portuguese). Retrieved 2023-10-02.
  3. ^ "Meet the P.I. - Muotri Lab - UC San Diego Department of Pediatrics". UC San Diego School of Medicine. Retrieved 2018-07-30.
  4. ^ Trujillo, Cleber A.; Gao, Richard; Negraes, Priscilla D.; Chaim, Isaac A.; Domissy, Alain; Vandenberghe, Matthieu; Devor, Anna; Yeo, Gene W.; Voytek, Bradley (2018-06-29). "Nested oscillatory dynamics in cortical organoids model early human brain network development". bioRxiv: 358622. doi:10.1101/358622. S2CID 90412858.
  5. ^ "With tweaks, brains in a dish may yield clear clues to autism | Spectrum | Autism Research News". Spectrum | Autism Research News. 2017-03-21.
  6. ^ "Alysson Muotri's Bibliography". www.ncbi.nlm.nih.gov. Retrieved 2018-07-30.
  7. ^ "Autism researcher Alysson Muotri's audacious plans for brain organoids". Spectrum | Autism Research News. 2019-08-12. Retrieved 2023-06-29.
  8. ^ "Muotri Lab". medschool.ucsd.edu. Retrieved 2023-06-29.
  9. ^ Teixeira Zorzanelli, Rafaela (January 2017). "Stem cell research in Brazil: the production of a new field of science". História, Ciências, Saúde. 24 (1). Retrieved 2023-06-29.
  10. ^ "Stem cell research finds a unique lab — the International Space Station". Washington Post. 2020-12-09. ISSN 0190-8286. Retrieved 2023-06-29.
  11. ^ "Autism researcher Alysson Muotri's audacious plans for brain organoids". Spectrum | Autism Research News. 2019-08-12. Retrieved 2023-06-29.
  12. ^ Muotri, Alysson R.; Nakashima, Kinichi; Toni, Nicolas; Sandler, Vladislav M.; Gage, Fred H. (2005). "Development of functional human embryonic stem cell-derived neurons in mouse brain". Proceedings of the National Academy of Sciences of the United States of America. 102 (51): 18644–18648. Bibcode:2005PNAS..10218644M. doi:10.1073/pnas.0509315102. ISSN 0027-8424. PMC 1317971. PMID 16352714.
  13. ^ Renewing the Stuff of Life: Stem Cells, Ethics, and Public Policy. Oxford, New York: Oxford University Press. 2007-06-25. ISBN 9780195305241.
  14. ^ Muotri, Alysson R.; Chu, Vi T.; Marchetto, Maria C. N.; Deng, Wei; Moran, John V.; Gage, Fred H. (June 2005). "Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition". Nature. 435 (7044): 903–910. Bibcode:2005Natur.435..903M. doi:10.1038/nature03663. hdl:2027.42/62714. ISSN 0028-0836. PMID 15959507. S2CID 4417661.
  15. ^ Hotz, Robert Lee (11 April 2006). "Brain's Darwin Machine". Los Angeles Times. Retrieved 2018-07-30.
  16. ^ Souza, Antônio Rodrigues de (1994-01-31). "E então que quereis, Maiakoviski ?". Revista Literária do Corpo Discente da Universidade Federal de Minas Gerais (in Brazilian Portuguese). 27 (25): 62. doi:10.17851/0103-5878.27.25.62 (inactive 1 November 2024). ISSN 0103-5878.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
  17. ^ Vogel, Gretchen (2011-04-15). "Do Jumping Genes Spawn Diversity?". Science. 332 (6027): 300–301. doi:10.1126/science.332.6027.300. ISSN 0036-8075. PMID 21493838.
  18. ^ "Shinya Yamanaka - Facts". www.nobelprize.org. Retrieved 2018-07-30.
  19. ^ Paiva Junior, Francisco (2011-04-02). "Uma luz no fim do microscópio". Revista Autismo.
  20. ^ Segatto, Cristiane (2010-11-11). "Esperança contra o autismo". Revista Época (in Brazilian Portuguese).
  21. ^ Marchetto, M. C.; Carromeu, C.; Acab, A.; Yu, D.; Yeo, G. W.; Mu, Y.; Chen, G.; Gage, F. H.; Muotri, A. R. (2010-11-12). "A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells". Cell. 143 (4): 527–539. doi:10.1016/j.cell.2010.10.016. PMC 3003590. PMID 21074045.
  22. ^ "'A cura é possível, é só uma questão de 'quando'', diz Alysson Muotri". O Globo (in Brazilian Portuguese). 2016-04-02.
  23. ^ "Mini-brain Model of Idiopathic Autism Reveals Underlying Pathology of Neuronal Overgrowth". UC Health - UC San Diego. Retrieved 2018-07-30.
  24. ^ "Lab-Grown Neurons From Autistic Kids Could Lead to New Treatments". WIRED.
  25. ^ "Com Ciência - SBPC/Labjor". www.comciencia.br. Retrieved 2018-07-30.
  26. ^ Chailangkarn, Thanathom; Trujillo, Cleber A.; Freitas, Beatriz C.; Hrvoj-Mihic, Branka; Herai, Roberto H.; Yu, Diana X.; Brown, Timothy T.; Marchetto, Maria C. N.; Bardy, Cedric (2016-08-18). "A human neurodevelopmental model for Williams syndrome". Nature. 536 (7616): 338–343. Bibcode:2016Natur.536..338C. doi:10.1038/nature19067. ISSN 0028-0836. PMC 4995142. PMID 27509850.
  27. ^ "Mini-brains made from teeth help reveal what makes us sociable". New Scientist.
  28. ^ "Tooth fairy delivers drug target for boosting social interest | Spectrum | Autism Research News". Spectrum | Autism Research News. 2016-09-16.
  29. ^ "Síndrome rara revela segredo por trás do cérebro social humano". O Globo (in Brazilian Portuguese). 2016-08-11.
  30. ^ Cugola, Fernanda R.; Fernandes, Isabella R.; Russo, Fabiele B.; Freitas, Beatriz C.; Dias, João L.M.; Guimarães, Katia P.; Benazzato, Cecília; Almeida, Nathalia; Pignatari, Graciela C. (2016-05-11). "The Brazilian Zika virus strain causes birth defects in experimental models". Nature. 534 (7606): 267–271. Bibcode:2016Natur.534..267C. doi:10.1038/nature18296. ISSN 0028-0836. PMC 4902174. PMID 27279226.
  31. ^ Wright, Jessica (2016-06-15). "How Autism Research and Mini-Brains Helped Prove Zika Causes Microcephaly". Slate. ISSN 1091-2339.
  32. ^ "UCSD Professor Finds Causal Link Between the Zika Virus and Microcephaly | THE TRITON". The Triton. 2016-06-09.
  33. ^ University of California Television (UCTV) (2018-07-25), CARTA: Imagination and Human Origins: Alysson Muotri - Reconstructing the Neanderthal Mind in a Dish, retrieved 2018-07-30
  34. ^ "Exclusive: Neanderthal 'minibrains' grown in dish". Science. 2018-06-20.
  35. ^ "G1 – Espiral – Alysson Muotri » Inovando na divulgação científica no Brasil » Arquivo". g1.globo.com (in Brazilian Portuguese). Retrieved 2018-04-14.
  36. ^ OAB/RJ. "Simples assim: células tronco – OAB/RJ". www.oabrj.org.br (in Brazilian Portuguese). Retrieved 2018-04-14.
  37. ^ "Livro sobre células-tronco será lançado no salão nobre da OAB/RJ". Jusbrasil (in Brazilian Portuguese).
  38. ^ "Palestra e Lançamento do Livro de Alysson Muotri sobre Autismo - A&R". Autismo & Realidade (in Brazilian Portuguese).
  39. ^ Saleh, Naíma. "EXCLUSIVO! Autismo: Nasce a primeira startup do mundo dedicada ao transtorno". Revista Crescer (in Brazilian Portuguese). Retrieved 2018-04-13.
  40. ^ "Cientistas brasileiros criam startups inovadoras em saúde | EXAME". exame.abril.com.br (in Brazilian Portuguese). Retrieved 2018-04-12.
  41. ^ "A Tismoo é a primeira startup que usa sequenciamento genético para entender e tratar o autismo no Brasil". Projeto Draft (in Brazilian Portuguese). 8 November 2016.
  42. ^ "Startup brasileira atua com medicina personalizada para o autismo - Saúde Business". Saúde Business (in Brazilian Portuguese).
  43. ^ "Novo laboratório em SP cria 'minicérebros' para tratamento de autismo". G1 (in Brazilian Portuguese).
  44. ^ Cugola, Fernanda R.; Fernandes, Isabella R.; Russo, Fabiele B.; Freitas, Beatriz C.; Dias, João L. M.; Guimarães, Katia P.; Benazzato, Cecília; Muotri, Alysson R.; Pignatari, Graciela C. (June 2016). "The Brazilian Zika virus strain causes birth defects in experimental models". Nature. 534 (7606): 267–271. Bibcode:2016Natur.534..267C. doi:10.1038/nature18296. ISSN 1476-4687. PMC 4902174. PMID 27279226.
  45. ^ Saraiva, Jacilio (2016-11-30). "Biotecnologia conquista novos nichos de mercado". Fapesp na Mídia (in Brazilian Portuguese).
  46. ^ Cugola, Fernanda R.; Fernandes, Isabella R.; Russo, Fabiele B.; Freitas, Beatriz C.; Dias, João L. M.; Guimarães, Katia P.; Benazzato, Cecília; Almeida, Nathalia; Pignatari, Graciela C. (2016-09-06). "The Brazilian Zika virus strain causes birth defects in experimental models". Nature. 534 (7606): 267–271. Bibcode:2016Natur.534..267C. doi:10.1038/nature18296. ISSN 1476-4687. PMC 4902174. PMID 27279226.
  47. ^ Bicudo, Lucas (2016-05-18). "Startup brasileira de biotecnologia tem trabalho reconhecido em uma das revistas mais respeitáveis de ciências | StartSe". StartSe (in Brazilian Portuguese).
  48. ^ "Autismo – startup brasileira atua com medicina personalizada". Revista News (in Brazilian Portuguese). 2018-01-15.
  49. ^ Saraiva, Jacilio (2016-11-30). "Biotecnologia conquista novos nichos de mercado". Valor Econômico (in Brazilian Portuguese).
  50. ^ "Tecnologia da TISMOO foi usada em pesquisa sobre zika vírus e publicada na Nature » DC Inovação » Diário do Comércio". DC Inovação. 2016-06-17. Archived from the original on 2018-04-14.
  51. ^ Monteiro, Rejane (2016-05-17). "Startup brasileira realiza feito inédito no mundo científico". Segs.com.br.
  52. ^ "Com 'minicérebro', start-up investiga terapias alternativas e ação da zika". Folha de S.Paulo. 23 October 2023.
  53. ^ Martins, Raphael (2018-04-09). "Muotri, da UC San Diego: Estamos perto da cura do zika | EXAME". Revista Exame (in Brazilian Portuguese).
  54. ^ Comércio, Diário do. "Tecnologia da TISMOO foi usada em pesquisa sobre zika vírus e publicada na Nature » DC Inovação » Diário do Comércio". Diário do Comércio. Archived from the original on 2018-04-14. Retrieved 2018-04-14.
  55. ^ "Cientista Alysson Muotri lança livro com artigos de dez anos de sua coluna no G1". G1 (in Brazilian Portuguese).
  56. ^ Paiva Junior, Francisco (2017-03-17). "A nata da pesquisa sobre autismo | Paiva Junior". PaivaJunior.com.br (in Brazilian Portuguese). Retrieved 2018-04-14.
  57. ^ Martins, Raphael (2018-04-09). "Muotri, da UC San Diego: Estamos perto da cura do zika | EXAME". Revista Exame (in Brazilian Portuguese). Retrieved 2018-04-14.
  58. ^ "Remédio pode curar o Zika – e evitar transmissão para bebês". Superinteressante (in Brazilian Portuguese).
  59. ^ "Cientista brasileiro descobre remédio que pode proteger fetos contra o Zika vírus - Saúde Business". Saúde Business (in Brazilian Portuguese).
  60. ^ Costa, Camilla (2018-02-04). "Biólogo brasileiro aposta em medicamento contra hepatite C para curar o Zika vírus". R7.com (in Brazilian Portuguese).
  61. ^ "Muotri, da UC San Diego: Estamos perto da cura do zika | EXAME". exame.abril.com.br (in Brazilian Portuguese). Retrieved 2018-04-14.
  62. ^ Muotri, Alysson R.; Macia, Angela; Moore, Spencer M.; Shiryaev, Sergey A.; Pinto, Antonella; Huang, Chun-Teng; Tejwani, Leon; Fernandes, Isabella R.; Suarez, Nicole A. (2018). "Blocking Zika virus vertical transmission". Scientific Reports. 8 (1): 1218. Bibcode:2018NatSR...8.1218M. doi:10.1038/s41598-018-19526-4. ISSN 2045-2322. PMC 5775359. PMID 29352135.
  63. ^ Costa, Camilla (2018-02-04). "Biólogo brasileiro aposta em medicamento contra hepatite C para curar o Zika vírus". BBC Brasil (in Brazilian Portuguese).
  64. ^ Northon, Karen (2019-07-25). "SpaceX Dragon en Route to Space Station with NASA Science, Cargo". NASA. Retrieved 2019-07-31.
  65. ^ "2019: A Space Organoid". UC Health - UC San Diego. Retrieved 2019-07-31.
  66. ^ "Cofundador da Tismoo envia minicérebros para o espaço em missão da Nasa e SpaceX". tismoo.us. 26 July 2019. Retrieved 2019-07-31.
  67. ^ "Cientista brasileiro envia 'minicérebros' para o espaço para desvendar reação das células". G1 (in Brazilian Portuguese). 20 July 2019. Retrieved 2019-07-31.
  68. ^ "Muotri envia 2ª etapa de sua pesquisa com 'minicérebros' humanos para o espaço". Revista Autismo (in Brazilian Portuguese). 2020-12-15. Retrieved 2021-01-13.
  69. ^ "Muotri envia 2ª etapa de sua pesquisa com minicérebros humanos para o espaço". Tismoo (in Brazilian Portuguese). 2020-11-27. Retrieved 2021-01-13.
  70. ^ "Com minicérebros, Muotri encontra 2 medicamentos candidatos a tratar Síndrome de Rett". Tismoo (in Brazilian Portuguese). Portal da Tismoo. 2020-12-09. Retrieved 2021-01-13.
  71. ^ "Estação Espacial Internacional pode receber primeiro cientista brasileiro". Ministério da Ciência, Tecnologia e Inovação (in Brazilian Portuguese). Retrieved 2023-10-01.
  72. ^ "Quem é Alysson Muotri, o primeiro cientista brasileiro que deve ir ao espaço". G1 (in Brazilian Portuguese). 2023-07-01. Retrieved 2023-10-01.
  73. ^ "Resposta para o autismo e o Alzheimer pode estar no espaço, diz 1º cientista brasileiro que irá à ISS". Folha de S.Paulo (in Brazilian Portuguese). 2023-07-22. Retrieved 2023-10-01.
  74. ^ "Cientista brasileiro escalado para missão espacial abrirá seleção para levar pesquisas nacionais". G1 (in Brazilian Portuguese). 2023-07-03. Retrieved 2024-01-30.
  75. ^ "Nasa: as cientistas brasileiras que lançaram experimento na Estação Espacial Internacional". BBC News Brasil (in Brazilian Portuguese). 2023-12-07. Retrieved 2024-01-30.
  76. ^ Vilicic, Filipe (2024-05-01). "O cientista Alysson Muotri fala de experiências brisadas e de ir pro espaço". Breeza (in Brazilian Portuguese). Retrieved 2024-05-03.
  77. ^ "Introvertendo 109- Neurodiversidade: Os Autistas". Introvertendo. 16 June 2020. Retrieved 2020-10-16.
  78. ^ "Os quatro reinos autistas". G1. Retrieved 2020-10-16.
  79. ^ "Alysson Muotri: para ele, a cura é um fato. Basta alcançá-la". Medictando. Retrieved 2020-10-16.
  80. ^ "Alysson Renato Muotri, Ph.D." www.pewtrusts.org. Retrieved 2018-08-06.
  81. ^ generator, metatags. "Project Information - NIH RePORTER - NIH Research Portfolio Online Reporting Tools Expenditures and Results". projectreporter.nih.gov. Retrieved 2018-08-06.
  82. ^ "UC San Diego's Alysson Muotri named 2011 Poptech Science Fellow". UC San Diego School of Medicine. Retrieved 2018-08-06.
  83. ^ "RFA-MH-14-214: Exceptional Unconventional Research Enabling Knowledge Acceleration (EUREKA) for Neuroscience and Disorders of the Nervous System (R01)". grants.nih.gov. Retrieved 2018-08-06.
  84. ^ "Alysson R. Muotri, Ph.D." Brain & Behavior Research Foundation. 2017-03-22.
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