Alphapolyomavirus is one of eight genera of non-enveloped dsDNA viruses in the polyomaviridae family.[1][2] Member viruses primarily infect humans and other mammals.[3] Transmission of the virus in humans is primarily spread via direct contact with parents or other high-contact individuals as children.[4][5]
| Alphapolyomavirus | |
|---|---|
| |
| Alphapolyomavirus model with a non-enveloped capsid and a T = 7d icosahedral symmetry at a 50 nm diameter scale. | |
Virus classification 
| |
| (unranked): | Virus |
| Realm: | Monodnaviria |
| Kingdom: | Shotokuvirae |
| Phylum: | Cossaviricota |
| Class: | Papovaviricetes |
| Order: | Sepolyvirales |
| Family: | Polyomaviridae |
| Genus: | Alphapolyomavirus |
The primary alphapolyomavirus that is of clinical significance to humans is Merkel cell polyomavirus (Human polyomavirus 5, MCV, or MCPyV). The apparent oncogenicity of MCPyV[6] similar to other cancer-causing viruses such as HPV, Epstein-Barr virus, and Hepatitis C virus[7] is a main area of research for the scientific community.
References
edit- ^ taxonomy. "Taxonomy browser (Polyomaviridae)". www.ncbi.nlm.nih.gov. Retrieved 2024-03-19.
- ^ "Alphapolyomavirus ~ ViralZone". viralzone.expasy.org. Retrieved 2024-03-19.
- ^ "Genus: Alphapolyomavirus | ICTV". ictv.global. Retrieved 2024-03-19.
- ^ Kunitake, T; Kitamura, T; Guo, J; Taguchi, F; Kawabe, K; Yogo, Y (Jun 1995). "Parent-to-child transmission is relatively common in the spread of the human polyomavirus JC virus". Journal of Clinical Microbiology. 33 (6): 1448–1451. doi:10.1128/jcm.33.6.1448-1451.1995. ISSN 0095-1137. PMC 228193. PMID 7650165.
- ^ Boothpur, Raghavender; Brennan, Daniel C. (Apr 2010). "Human Polyoma Viruses and Disease with Emphasis on Clinical BK and JC". Journal of Clinical Virology. 47 (4): 306–312. doi:10.1016/j.jcv.2009.12.006. ISSN 1386-6532. PMC 3774018. PMID 20060360.
- ^ Spurgeon, Megan E.; Lambert, Paul F. (2013-01-05). "Merkel Cell Polyomavirus: A Newly Discovered Human Virus with Oncogenic Potential". Virology. 435 (1): 118–130. doi:10.1016/j.virol.2012.09.029. ISSN 0042-6822. PMC 3522868. PMID 23217622.
- ^ "Gale – Product Login". galeapps.gale.com. Retrieved 2024-03-19.