AH receptor-interacting protein (AIP ) also known as aryl hydrocarbon receptor-interacting protein , immunophilin homolog ARA9 , or HBV X-associated protein 2 (XAP-2 ) is a protein that in humans is encoded by the AIP gene .[ 5] [ 6] [ 7] FKBP family.
AIP may play a positive role in aryl hydrocarbon receptor -mediated signalling possibly by influencing its receptivity for ligand and/or its nuclear targeting. AIP is the cellular negative regulator of the hepatitis B virus (HBV) X protein.[ 5] [ 8] [ 9]
Mutations and role in disease
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AIP mutations may be the cause of a familial form of acromegaly , familial isolated pituitary adenoma (FIPA). Somatotropinomas (i.e. GH -producing pituitary adenomas ), sometimes associated with prolactinomas , are present in most AIP mutated patients.[ 10]
^ a b c GRCh38: Ensembl release 89: ENSG00000110711 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024847 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: AIP aryl hydrocarbon receptor interacting protein" .^ Kuzhandaivelu N, Cong YS, Inouye C, Yang WM, Seto E (December 1996). "XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation" . Nucleic Acids Res . 24 (23): 4741–50. doi :10.1093/nar/24.23.4741 . PMC 146319 PMID 8972861 . ^ a b c Carver LA, Bradfield CA (April 1997). "Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo" . J. Biol. Chem . 272 (17): 11452–6. doi :10.1074/jbc.272.17.11452 PMID 9111057 . ^ a b Zhou Q, Lavorgna A, Bowman M, Hiscott J, Harhaj EW (June 2015). "Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon" . The Journal of Biological Chemistry . 290 (23): 14729–39. doi :10.1074/jbc.M114.633065 PMC 4505538 PMID 25911105 . ^ Petrulis JR, Perdew GH (2002). "The role of chaperone proteins in the aryl hydrocarbon receptor core complex". Chemico-Biological Interactions . 141 (1–2): 25–40. Bibcode :2002CBI...141...25P . doi :10.1016/S0009-2797(02)00064-9 . PMID 12213383 . ^ Occhi G, Trivellin G, Ceccato F, et al. (2010). "Prevalence of AIP mutations in a large series of sporadic Italian acromegalic patients and evaluation of CDKN1B status in acromegalic patients with multiple endocrine neoplasia" . Eur. J. Endocrinol . 163 (3): 369–376. doi :10.1530/EJE-10-0327 PMID 20530095 . ^ Petrulis JR, Hord NG, Perdew GH (December 2000). "Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2" . J. Biol. Chem . 275 (48): 37448–53. doi :10.1074/jbc.M006873200 PMID 10986286 . ^ Ma Q, Whitlock JP (April 1997). "A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin" . J. Biol. Chem . 272 (14): 8878–84. doi :10.1074/jbc.272.14.8878 PMID 9083006 . ^ Sumanasekera WK, Tien ES, Turpey R, Vanden Heuvel JP, Perdew GH (February 2003). "Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2" . J. Biol. Chem . 278 (7): 4467–73. doi :10.1074/jbc.M211261200 PMID 12482853 . ^ Kazlauskas A, Sundström S, Poellinger L, Pongratz I (April 2001). "The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor" . Mol. Cell. Biol . 21 (7): 2594–607. doi :10.1128/MCB.21.7.2594-2607.2001 . PMC 86890 PMID 11259606 .
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"Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity" . Mol. Cell. Biol . 18 (2): 978–88. doi :10.1128/MCB.18.2.978 . PMC 108810 PMID 9447995 . Carver LA, LaPres JJ, Jain S, et al. (1999). "Characterization of the Ah receptor-associated protein, ARA9" . J. Biol. Chem . 273 (50): 33580–7. doi :10.1074/jbc.273.50.33580 PMID 9837941 . Gadelha MR, Une KN, Rohde K, et al. (2000). "Isolated familial somatotropinomas: establishment of linkage to chromosome 11q13.1-11q13.3 and evidence for a potential second locus at chromosome 2p16-12" . J. Clin. Endocrinol. Metab . 85 (2): 707–14. doi :10.1210/jcem.85.2.6386 PMID 10690880 . Petrulis JR, Hord NG, Perdew GH (2001). "Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2" . J. Biol. Chem . 275 (48): 37448–53. doi :10.1074/jbc.M006873200 PMID 10986286 . 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