AGTRAP

Type-1 angiotensin II receptor-associated protein is a protein that in humans is encoded by the AGTRAP gene.

AGTRAP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZV0, 4YAY
Identifiers
Aliases	AGTRAP, ATRAP, angiotensin II receptor associated protein
External IDs	OMIM: 608729; MGI: 1339977; HomoloGene: 7621; GeneCards: AGTRAP; OMA:AGTRAP - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.22 Start 11,736,084 bp End 11,754,802 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 E1|4 78.67 cM Start 148,161,518 bp End 148,172,488 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte right uterine tube pancreatic ductal cell blood gastric mucosa spleen right lung upper lobe of left lung bone marrow Top expressed in blastocyst right kidney granulocyte choroid plexus of fourth ventricle proximal tubule gastrula Ileal epithelium yolk sac human kidney embryo More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding angiotensin type II receptor activity Cellular component integral component of membrane Golgi membrane plasma membrane Golgi apparatus cell cortex endoplasmic reticulum membrane cytoplasmic vesicle membrane intracellular membrane-bounded organelle endoplasmic reticulum membrane cytoplasmic vesicle nucleoplasm cytosol Biological process regulation of blood pressure angiotensin-activated signaling pathway response to hypoxia Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57085 11610 Ensembl ENSG00000177674 ENSMUSG00000029007 UniProt Q6RW13 Q9WVK0 RefSeq (mRNA) NM_001040194 NM_001040195 NM_001040196 NM_001040197 NM_020350 NM_001301281 NM_009642 RefSeq (protein) NP_001035284 NP_001035285 NP_001035286 NP_001035287 NP_065083 NP_001288210 NP_033772 Location (UCSC) Chr 1: 11.74 – 11.75 Mb Chr 4: 148.16 – 148.17 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.

Interactions

AGTRAP has been shown to interact with GNB2L1.

External links

• Human AGTRAP genome location and AGTRAP gene details page in the UCSC Genome Browser.

Further reading

• Daviet L, Lehtonen JY, Tamura K, et al. (1999). "Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor". J. Biol. Chem. 274 (24): 17058–62. doi:10.1074/jbc.274.24.17058. PMID 10358057.
• Cui T, Nakagami H, Iwai M, et al. (2001). "ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth". Biochem. Biophys. Res. Commun. 279 (3): 938–41. doi:10.1006/bbrc.2000.4055. PMID 11162453.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. PMID 12107413.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lopez-Ilasaca M, Liu X, Tamura K, Dzau VJ (2004). "The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling". Mol. Biol. Cell. 14 (12): 5038–50. doi:10.1091/mbc.E03-06-0383. PMC 284805. PMID 12960423.
• Guo DF, Chenier I, Tardif V, et al. (2003). "Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane". Biochem. Biophys. Res. Commun. 310 (4): 1254–65. doi:10.1016/j.bbrc.2003.09.154. PMID 14559250.
• Guo DF, Tardif V, Ghelima K, et al. (2004). "A novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells". J. Biol. Chem. 279 (20): 21109–20. doi:10.1074/jbc.M401544200. PMID 14985364.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Guo S, Lopez-Ilasaca M, Dzau VJ (2005). "Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation". J. Biol. Chem. 280 (13): 12536–41. doi:10.1074/jbc.M500296200. PMID 15668245.
• Tanaka Y, Tamura K, Koide Y, et al. (2005). "The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy". FEBS Lett. 579 (7): 1579–86. doi:10.1016/j.febslet.2005.01.068. PMID 15757644. S2CID 36456303.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.