Double-stranded RNA-specific editase 1 is an enzyme that in humans is encoded by the ADARB1 gene.[5][6][7] The enzyme is a member of ADAR family.

ADARB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADARB1, ADAR2, DRABA2, DRADA2, RED1, adenosine deaminase, RNA specific B1, adenosine deaminase RNA specific B1, NEDHYMS
External IDsOMIM: 601218; MGI: 891999; HomoloGene: 8280; GeneCards: ADARB1; OMA:ADARB1 - orthologs
EC number3.5.4.37
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001024837
NM_001024838
NM_001024839
NM_001024840
NM_130895

RefSeq (protein)

NP_001020008
NP_570965
NP_001020009

Location (UCSC)Chr 21: 45.07 – 45.23 MbChr 10: 77.13 – 77.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rats found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an Alu cassette insert and a short or long C-terminal region.[7]

ADARB1 requires the small molecule inositol hexakisphosphate (IP6) for proper function.[8] ADARB1 is an A-to-I RNA-editing enzyme that mostly acts on protein-coding substrates.[9]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197381Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020262Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mittaz L, Scott HS, Rossier C, Seeburg PH, Higuchi M, Antonarakis SE (April 1997). "Cloning of a human RNA editing deaminase (ADARB1) of glutamate receptors that maps to chromosome 21q22.3". Genomics. 41 (2): 210–7. doi:10.1006/geno.1997.4655. PMID 9143496.
  6. ^ Keegan LP, Leroy A, Sproul D, O'Connell MA (Feb 2004). "Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes". Genome Biology. 5 (2): 209. doi:10.1186/gb-2004-5-2-209. PMC 395743. PMID 14759252.
  7. ^ a b "Entrez Gene: ADARB1 adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)".
  8. ^ Macbeth MR, Schubert HL, Vandemark AP, Lingam AT, Hill CP, Bass BL (September 2005). "Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing". Science. 309 (5740): 1534–9. Bibcode:2005Sci...309.1534M. doi:10.1126/science.1113150. PMC 1850959. PMID 16141067.
  9. ^ Licht K, Jantsch MF (April 2016). "Rapid and dynamic transcriptome regulation by RNA editing and RNA modifications". The Journal of Cell Biology. 213 (1): 15–22. doi:10.1083/jcb.201511041. PMC 4828693. PMID 27044895.

Further reading

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