Alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase (EC 2.4.1.155, N-acetylglucosaminyltransferase V, alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase, UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase, alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase, GnTV) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:6-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase.[1][2] This enzyme catalyses the following chemical reaction
| Alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.155 | ||||||||
| CAS no. | 83588-90-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- UDP-N-acetyl-D-glucosamine + 6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R UDP + 6-(2,6-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor.
References
edit- ^ Cummings RD, Trowbridge IS, Kornfeld S (November 1982). "A mouse lymphoma cell line resistant to the leukoagglutinating lectin from Phaseolus vulgaris is deficient in UDP-GlcNAc: alpha-D-mannoside beta 1,6 N-acetylglucosaminyltransferase". The Journal of Biological Chemistry. 257 (22): 13421–7. PMID 6216250.
- ^ Hindsgaul O, Tahir SH, Srivastava OP, Pierce M (March 1988). "The trisaccharide beta-D-GlcpNAc-(1----2)-alpha-D-Manp-(1----6)-beta-D-Manp, as its 8-methoxycarbonyloctyl glycoside, is an acceptor selective for N-acetylglucosaminyltransferase V". Carbohydrate Research. 173 (2): 263–72. doi:10.1016/s0008-6215(00)90822-x. PMID 2834054.
External links
edit- Alpha-1,6-mannosyl-glycoprotein+6-beta-N-acetylglucosaminyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
