Former Grand Island town supervisor and 2018 Democratic congressional nominee Nathan D. McMurray was expected to be the nominee after being endorsed by the Erie County Democratic Party.[3] Fellow Democrat Melodie Baker announced her interest in seeking the nomination, but quickly withdrew when her campaign failed to gain interest.[4] McMurray was formally nominated on February 13, 2020.[5]
On January 25, 2020, the Republican chairs of the eight counties that make up the 27th congressional district met in Wyoming County and voted to endorse state senator Chris Jacobs for the special election.[6]
On February 1, 2020, the Conservative Party of New York State announced that it would not endorse a candidate in the anticipated special election and would instead leave its party line blank. The Party's preferred candidate was Beth Parlato.[7]
Accountant Duane Whitmer was endorsed by the Libertarian Party.[8][9]
McMurray and Jacobs participated in a debate on June 9, in which McMurray criticized Jacobs for not standing up to Trump's actions, in particular, Trump's claim that a 75-year-old man injured by police in Buffalo could be an "ANTIFA provocateur". McMurray also accused Jacobs of trying to buy the position, lying, and not supporting the Black Lives Matter movement. He emphasized his continued positive impact on communities in the area, positioning himself as an alternative to former Republican representatives Chris Collins and Chris Lee, both of whom resigned due to scandals. Jacobs criticized McMurray for supporting big government and abortion, which he saw as a poor fit for the conservative values of the district.[23]