This article lists important figures and events in Malaysian public affairs during the year 2010, together with the deaths of notable Malaysians. Malaysia Day, 16 September was celebrated as a national holiday for the first time.
10 January – A church and a school guard post in Taiping, Perak had Molotov cocktails thrown at them. There was no damage to the All Saints Church in Jalan Taming Sari while the guard post at Convent High School suffered only minor damage.
29 January – Shah Alam Member of Parliament, Khalid Abdul Samad was suspended for six months as Shah Alam PAS chief and member of the party's political bureau by the PAS discipline committee.
20 February – Penang Hill's iconic funicular train made its final run after 87 years. It would be replaced by a RM63 mil upgraded system seven months later.
23 February – Much of the 200-year-old Ho Ann Kiong Chinese temple in the Chinatown Kuala Terengganu, Terengganu was destroyed by fire.
23 February – A Malaysian consular employee was stabbed to death outside his home in a suspected road-rage incident in Sydney, Australia.
15 April – Bakar Arang, Kedah's state assemblyman Tan Wei Shu quit the Parti Keadilan Rakyat (PKR) party.
17 April – Achik Spin (real name Abdillah Murad Md Shari), vocalist of Malaysian rock band Spin died in a car accident on Kajang–Seremban Highway near Pajam, Negeri Sembilan.
26 April – A 15-year-old boy Aminulrasyid Amzah was shot dead while reversing his car in an attempt to run over several policemen in Shah Alam, Selangor.
20 June – The 115-year-old Pudu Prison's wall between Jalan Pudu and Jalan Hang Tuah, Kuala Lumpur was demolished to make way for a road-widening project, which included the construction of an underpass at Jalan Pudu–Hang Tuah junctions.
6 July–22 August – A population census was carried out, results showing the nation's population to be 28,334,135.
9 July – Proton cars celebrated its 25th anniversary. Launch of the Proton EMAS prototype cars.
16 July – The federal government announced a reduction in subsidies for fuel and sugar.
26 July – Heavy vehicles were banned during peak hours in the morning to ease congestion on certain routes of the PLUS Expressways in the Klang Valley, beginning 2 August.
13 August – Two people were killed and two others injured in a freak storm at a Ramadan bazaar in Jasin, Malacca.
14 August – A man ran amok and killed his wife at their home in Langkap near Teluk Intan, Perak.
16 August – Pasir Mas Deputy RELA Chief Harun Abdullah, who was reported missing on Friday 13 August, was found dead near a railway track in Tumpat, Kelantan.
17 August – Four in a family of six were killed when their car collided with a van at Km 22 of Jalan Seremban–Simpang Pertang road in Bukit Tangga near Kuala Klawang in Jelebu, Negeri Sembilan.
22 August – A 6-year-old boy was killed and two men were injured in an explosion at an abandoned house used to store fireworks and firecrackers at Kampung Seberang Baroh in Cabang Tiga near Kuala Terengganu, Terengganu.
23 August – Vandals splashed red paint on a surau in Taman Pulai Impian, Sikamat, Negeri Sembilan and left a broken beer bottle there.
6 October – A monkey killed a four-day-old baby girl sleeping in the living room of her family's home in Seremban, Negeri Sembilan.
7 October – Six fishermen were missing and 11 were saved when a merchant ship rammed into their boat in the Straits of Malacca, about 10 nautical miles (19 km) off Sabak Bernam, Selangor.
9 October – From 2016 onwards, the Penilaian Menengah Rendah (PMR) examination for Form Three students would be replaced with a school-based assessment to be drawn up by the Malaysian Examination Institution (Lembaga Peperiksaan Malaysia).
15 October – Malaysian Parliament celebrated its 50th anniversary of the formation.
15 October – The RM5 billion landmark Warisan Merdeka project, including a 100-storey tower in Kuala Lumpur was announced during the 2011 Budget.
16 October – Beginning next year, all Year One pupils will be studying Science and Mathematics in Bahasa Malaysia (Malay Language), ahead of the initial 2012 target. Their textbooks will also be in Bahasa Malaysia.
18 October – Six people are dead and up to seven people are feared missing after a ferry collided with a tugboat in the Anap river, Sarawak.
20 October – Melaka declared as a developed state in Malaysia.
25 October – Nine agreements worth at least RM 30 billion have been inked between the Government and the private sector, boosting the RM 1.3 trillion Economic Transformation Programme (ETP).
7 November – Sixteen people, one of them a four-year-old boy, survived an 18-hour ordeal floating at sea after their boat sank near Pulau Tenggol off Dungun, Terengganu.
8 November – Eight workers were injured in the motorcycle rim factory blast at Perai, Penang.
6 December – Former Selangor Mentri Besar Datuk Seri Dr Mohd Khir Toyo was charged with land fraud involving two plots of land and a house in Shah Alam worth millions of ringgit.
9 December – South Korean President Lee Myung-bak made a two-day state visit to Malaysia in conjunction with the 50th anniversary of diplomatic relations between both countries.