Jan-Michael Gambill and Scott Humphries were the defending champions but they competed with different partners that year, Gambill with Jonathan Stark and Humphries with Justin Gimelstob.
| Doubles | |
|---|---|
| 2001 Sybase Open | |
| Champions |  Mark Knowles  Brian MacPhie |
| Runners-up | Jan-Michael Gambill Jonathan Stark |
| Score | 6–3, 7–6(7–4) |
| Draw | 16 |
| Seeds | 4 |
Gimelstob and Humphries lost in the quarterfinals to Simon Aspelin and Johan Landsberg.
Gambill and Stark lost in the final 6–3, 7–6(7–4) against Mark Knowles and Brian MacPhie.
Seeds
editChampion seeds are indicated in bold text while text in italics indicates the round in which those seeds were eliminated.
Sébastien Lareau / 
Alex O'Brien (quarterfinals)- Justin Gimelstob / Scott Humphries (quarterfinals)
Neville Godwin / Rick Leach (quarterfinals)
Mark Knowles / Brian MacPhie (champions)
Draw
editKey
edit- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 |  S Lareau A O'Brien
| 6 | 7 | ||||||||||||||||||||||||
| WC | L Jensen M Jensen
| 2 | 5 | 1 | S Lareau A O'Brien
| 3 | 3 | ||||||||||||||||||||
| J Palmer C Woodruff
| 6 | 6 | J Palmer C Woodruff
| 6 | 6 | ||||||||||||||||||||||
| B Bryan M Bryan
| 4 | 3 | J Palmer C Woodruff
| 62 | 3 | ||||||||||||||||||||||
| 4 | M Knowles B MacPhie
| 6 | 78 | 4 | M Knowles B MacPhie
| 77 | 6 | ||||||||||||||||||||
 T Shimada M Wakefield
| 2 | 66 | 4 | M Knowles B MacPhie
| 6 | 2 | 6 | ||||||||||||||||||||
| WC | P Goldstein J Thomas
| 3 | 7 | 6 | WC | P Goldstein J Thomas
| 3 | 6 | 3 | ||||||||||||||||||
 W Arthurs B Ellwood
| 6 | 5 | 3 | 4 | Mark Knowles Brian MacPhie
| 6 | 77 | ||||||||||||||||||||
| J-M Gambill J Stark
| 6 | 67 | 6 | Jan-Michael Gambill Jonathan Stark
| 3 | 64 | |||||||||||||||||||||
 J Balcells A Kratzmann
| 3 | 79 | 3 | J-M Gambill J Stark
| 6 | 1 | 6 | ||||||||||||||||||||
| WC |  T Haas G Weiner
| 1 | 65 | 3 | N Godwin R Leach
| 1 | 6 | 3 | |||||||||||||||||||
| 3 | N Godwin R Leach
| 6 | 77 | J-M Gambill J Stark
| 77 | 78 | |||||||||||||||||||||
| D Macpherson G Stafford
| 63 | 3 |  S Aspelin J Landsberg
| 64 | 66 | ||||||||||||||||||||||
| S Aspelin J Landsberg
| 77 | 6 | S Aspelin J Landsberg
| 6 | 710 | ||||||||||||||||||||||
| Q |  H Levy A Sá
| 3 | 64 | 2 | J Gimelstob S Humphries
| 3 | 68 | ||||||||||||||||||||
| 2 | J Gimelstob S Humphries
| 6 | 77 | ||||||||||||||||||||||||