Zinc finger protein 521

Zinc finger protein 521 is a protein that in humans is encoded by the ZNF521 gene.

ZNF521
Identifiers
Aliases	ZNF521, EHZF, Evi3, zinc finger protein 521
External IDs	OMIM: 610974; MGI: 95459; HomoloGene: 9151; GeneCards: ZNF521; OMA:ZNF521 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) Band 18q11.2 Start 25,061,924 bp End 25,352,190 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18 A1|18 7.68 cM Start 13,820,070 bp End 14,105,844 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis buccal mucosa cell Achilles tendon cerebellar hemisphere right hemisphere of cerebellum pons sural nerve tendon of biceps brachii synovial joint synovial membrane Top expressed in lobe of cerebellum cerebellar vermis condyle genital tubercle endocardial cushion atrioventricular valve mandibular prominence tail of embryo atrium trigeminal ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein domain specific binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus extracellular region Biological process multicellular organism development neuron fate commitment cell differentiation regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25925 225207 Ensembl ENSG00000198795 ENSMUSG00000024420 UniProt Q96K83 Q8IYZ2 Q6KAS7 RefSeq (mRNA) NM_001308225 NM_015461 NM_145492 NM_001360804 RefSeq (protein) NP_001295154 NP_056276 NP_001295154.1 NP_663467 NP_001347733 Location (UCSC) Chr 18: 25.06 – 25.35 Mb Chr 18: 13.82 – 14.11 Mb PubMed search
Wikidata
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Further reading

• La Rocca R, Fulciniti M, Lakshmikanth T, Mesuraca M, Ali TH, Mazzei V, Amodio N, Catalano L, Rotoli B, Ouerfelli O, Grieco M, Gulletta E, Bond HM, Morrone G, Ferrone S, Carbone E (April 2009). "Early hematopoietic zinc finger protein prevents tumor cell recognition by natural killer cells". Journal of Immunology. 182 (8): 4529–37. doi:10.4049/jimmunol.0802109. PMC 2747523. PMID 19342626.
• Bond HM, Mesuraca M, Amodio N, Mega T, Agosti V, Fanello D, Pelaggi D, Bullinger L, Grieco M, Moore MA, Venuta S, Morrone G (2008). "Early hematopoietic zinc finger protein-zinc finger protein 521: a candidate regulator of diverse immature cells". The International Journal of Biochemistry & Cell Biology. 40 (5): 848–54. doi:10.1016/j.biocel.2007.04.006. PMID 17543573.
• Warming S, Liu P, Suzuki T, Akagi K, Lindtner S, Pavlakis GN, Jenkins NA, Copeland NG (March 2003). "Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Krüppel-like zinc finger protein". Blood. 101 (5): 1934–40. doi:10.1182/blood-2002-08-2652. PMID 12393497.
• Matsubara E, Sakai I, Yamanouchi J, Fujiwara H, Yakushijin Y, Hato T, Shigemoto K, Yasukawa M (February 2009). "The role of zinc finger protein 521/early hematopoietic zinc finger protein in erythroid cell differentiation". The Journal of Biological Chemistry. 284 (6): 3480–7. doi:10.1074/jbc.M805874200. PMID 19049973.
• Bond HM, Mesuraca M, Carbone E, Bonelli P, Agosti V, Amodio N, De Rosa G, Di Nicola M, Gianni AM, Moore MA, Hata A, Grieco M, Morrone G, Venuta S (March 2004). "Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells". Blood. 103 (6): 2062–70. doi:10.1182/blood-2003-07-2388. PMID 14630787.
• McCormack M, Urban TJ, Shianna KV, Walley N, Pandolfo M, Depondt C, Chaila E, O'Conner GD, Kasperavičiūtė D, Radtke RA, Heinzen EL, Sisodiya SM, Delanty N, Cavalleri GL (March 2012). "Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions". Pharmacogenomics. 13 (4): 399–405. doi:10.2217/pgs.11.165. PMC 3428903. PMID 22379998.
• Hesse E, Kiviranta R, Wu M, Saito H, Yamana K, Correa D, Atfi A, Baron R (March 2010). "Zinc finger protein 521, a new player in bone formation". Annals of the New York Academy of Sciences. 1192 (1): 32–7. Bibcode:2010NYASA1192...32H. doi:10.1111/j.1749-6632.2009.05347.x. PMID 20392215. S2CID 29853724.
• Tchernev VT, Mansfield TA, Giot L, Kumar AM, Nandabalan K, Li Y, Mishra VS, Detter JC, Rothberg JM, Wallace MR, Southwick FS, Kingsmore SF (January 2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Molecular Medicine. 8 (1): 56–64. doi:10.1007/BF03402003. PMC 2039936. PMID 11984006.
• Spina R, Filocamo G, Iaccino E, Scicchitano S, Lupia M, Chiarella E, Mega T, Bernaudo F, Pelaggi D, Mesuraca M, Pazzaglia S, Semenkow S, Bar EE, Kool M, Pfister S, Bond HM, Eberhart CG, Steinkühler C, Morrone G (August 2013). "Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells". Oncotarget. 4 (8): 1280–92. doi:10.18632/oncotarget.1176. PMC 3787157. PMID 23907569.