ZNF451

Zinc finger protein 451 is a novel nuclear protein that in humans is encoded by the ZNF451 gene.

ZNF451
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5D2M
Identifiers
Aliases	ZNF451, COASTER, dJ417I1.1, zinc finger protein 451, ZATT
External IDs	OMIM: 615708; MGI: 2137896; HomoloGene: 9188; GeneCards: ZNF451; OMA:ZNF451 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p12.1 Start 57,086,844 bp End 57,170,305 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 B|1 12.81 cM Start 33,800,626 bp End 33,853,676 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum Achilles tendon trabecular bone tibia right testis bone marrow nipple left testis lower lobe of lung sural nerve Top expressed in spermatid Rostral migratory stream medial ganglionic eminence zygote secondary oocyte tail of embryo genital tubercle Gonadal ridge primary oocyte trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SUMO ligase activity transcription corepressor activity protein binding metal ion binding nucleic acid binding transferase activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II core promoter sequence-specific DNA binding Cellular component PML body nucleus nucleoplasm histone methyltransferase complex Biological process negative regulation of transcription initiation from RNA polymerase II promoter negative regulation of histone H3-K9 acetylation regulation of transcription, DNA-templated negative regulation of transforming growth factor beta receptor signaling pathway protein sumoylation transcription, DNA-templated regulation of gene expression Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26036 98403 Ensembl ENSG00000112200 ENSMUSG00000042197 UniProt Q9Y4E5 Q8C0P7 RefSeq (mRNA) NM_001031623 NM_001257273 NM_015555 NM_001290699 NM_001290700 NM_133817 NM_001359274 NM_001359275 RefSeq (protein) NP_001026794 NP_001244202 NP_056370 NP_001277628 NP_001277629 NP_598578 NP_001346203 NP_001346204 Location (UCSC) Chr 6: 57.09 – 57.17 Mb Chr 1: 33.8 – 33.85 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

• ZNF451+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.