ZNF217

Zinc finger protein 217, also known as ZNF217, is a protein which in humans is encoded by the ZNF217 gene.

ZNF217
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HU2, 3UK3, 4F2J, 4IS1
Identifiers
Aliases	ZNF217, ZABC1, zinc finger protein 217
External IDs	OMIM: 602967; MGI: 2685408; HomoloGene: 4757; GeneCards: ZNF217; OMA:ZNF217 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20q13.2 Start 53,567,071 bp End 53,609,907 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 H3|2 89.91 cM Start 169,950,563 bp End 169,990,023 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium palpebral conjunctiva buccal mucosa cell epithelium of nasopharynx white blood cell monocyte mucosa of sigmoid colon cartilage tissue tonsil lactiferous duct Top expressed in granulocyte spermatid medullary collecting duct renal corpuscle Gonadal ridge primitive streak conjunctival fornix bone marrow otolith organ lymph node More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component histone deacetylase complex nucleus mitochondrion nuclear speck nucleoplasm Biological process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated signal transduction multicellular organism development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7764 228913 Ensembl ENSG00000171940 ENSMUSG00000052056 UniProt O75362 Q3U0X6 RefSeq (mRNA) NM_006526 NM_001385034 NM_001033299 NM_001159683 RefSeq (protein) NP_006517 NP_001028471 NP_001153155 Location (UCSC) Chr 20: 53.57 – 53.61 Mb Chr 2: 169.95 – 169.99 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

ZNF217 can attenuate apoptotic signals resulting from telomere dysfunction and may promote neoplastic transformation and later stages of malignancy. Znf217 was shown to be a prognostic biomarker and therapeutic target during breast cancer progression.

See also

• Zinc finger

Further reading

• Quinlan KG, Verger A, Yaswen P, Crossley M (Jun 2007). "Amplification of zinc finger gene 217 (ZNF217) and cancer: when good fingers go bad". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1775 (2): 333–40. doi:10.1016/j.bbcan.2007.05.001. PMID 17572303. S2CID 30704436.
• Kallioniemi A, Kallioniemi OP, Piper J, Tanner M, Stokke T, Chen L, Smith HS, Pinkel D, Gray JW, Waldman FM (Mar 1994). "Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization". Proceedings of the National Academy of Sciences of the United States of America. 91 (6): 2156–60. Bibcode:1994PNAS...91.2156K. doi:10.1073/pnas.91.6.2156. PMC 43329. PMID 8134364.
• Collins C, Rommens JM, Kowbel D, Godfrey T, Tanner M, Hwang SI, Polikoff D, Nonet G, Cochran J, Myambo K, Jay KE, Froula J, Cloutier T, Kuo WL, Yaswen P, Dairkee S, Giovanola J, Hutchinson GB, Isola J, Kallioniemi OP, Palazzolo M, Martin C, Ericsson C, Pinkel D, Albertson D, Li WB, Gray JW (Jul 1998). "Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 95 (15): 8703–8. Bibcode:1998PNAS...95.8703C. doi:10.1073/pnas.95.15.8703. PMC 21140. PMID 9671742.
• Nonet GH, Stampfer MR, Chin K, Gray JW, Collins CC, Yaswen P (Feb 2001). "The ZNF217 gene amplified in breast cancers promotes immortalization of human mammary epithelial cells". Cancer Research. 61 (4): 1250–4. PMID 11245413.
• Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (Feb 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.
• Weiss MM, Snijders AM, Kuipers EJ, Ylstra B, Pinkel D, Meuwissen SG, van Diest PJ, Albertson DG, Meijer GA (Jul 2003). "Determination of amplicon boundaries at 20q13.2 in tissue samples of human gastric adenocarcinomas by high-resolution microarray comparative genomic hybridization". The Journal of Pathology. 200 (3): 320–6. doi:10.1002/path.1359. PMID 12845628. S2CID 10753746.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Shimada M, Imura J, Kozaki T, Fujimori T, Asakawa S, Shimizu N, Kawaguchi R (Apr 2005). "Detection of Her2/neu, c-MYC and ZNF217 gene amplification during breast cancer progression using fluorescence in situ hybridization". Oncology Reports. 13 (4): 633–41. doi:10.3892/or.13.4.633. PMID 15756435.
• Huang G, Krig S, Kowbel D, Xu H, Hyun B, Volik S, Feuerstein B, Mills GB, Stokoe D, Yaswen P, Collins C (Nov 2005). "ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction". Human Molecular Genetics. 14 (21): 3219–25. doi:10.1093/hmg/ddi352. PMID 16203743.
• Quinlan KG, Nardini M, Verger A, Francescato P, Yaswen P, Corda D, Bolognesi M, Crossley M (Nov 2006). "Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins". Molecular and Cellular Biology. 26 (21): 8159–72. doi:10.1128/MCB.00680-06. PMC 1636751. PMID 16940172.
• Cowger JJ, Zhao Q, Isovic M, Torchia J (May 2007). "Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence". Oncogene. 26 (23): 3378–86. doi:10.1038/sj.onc.1210126. PMID 17130829. S2CID 19636585.

External links

• ZNF217+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)