ZFP36L1

Butyrate response factor 1 is a protein that in humans is encoded by the ZFP36L1 gene.

ZFP36L1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W0V, 1W0W
Identifiers
Aliases	ZFP36L1, BRF1, Berg36, ERF-1, ERF1, RNF162B, TIS11B, cMG1, ZFP36 ring finger protein-like 1, ZFP36 ring finger protein like 1
External IDs	OMIM: 601064; MGI: 107946; HomoloGene: 31276; GeneCards: ZFP36L1; OMA:ZFP36L1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q24.1 Start 68,787,660 bp End 68,796,253 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 C3 Start 80,154,528 bp End 80,159,787 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of paranasal sinus canal of the cervix gastric mucosa right ovary ectocervix nipple left ovary urethra body of uterus right uterine tube Top expressed in corneal stroma genital tubercle ventricular zone lactiferous gland lip yolk sac esophagus cardiac muscle tissue of left ventricle superior surface of tongue atrium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity metal ion binding protein binding mRNA binding 14-3-3 protein binding RNA binding mRNA 3'-UTR AU-rich region binding DNA-binding transcription factor activity, RNA polymerase II-specific mRNA 3'-UTR binding Cellular component cytoplasm nucleus cytosol P-body ribonucleoprotein complex Biological process spongiotrophoblast layer development mRNA catabolic process multicellular organism growth embryonic organ development chorio-allantoic fusion vasculogenesis proepicardium development heart development nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay neural tube development cell population proliferation regulation of translation apoptotic process T cell differentiation in thymus regulation of gene expression negative regulation of erythrocyte differentiation cellular response to insulin stimulus cellular response to phorbol 13-acetate 12-myristate ERK1 and ERK2 cascade positive regulation of intracellular mRNA localization cellular response to glucocorticoid stimulus cellular response to transforming growth factor beta stimulus regulation of keratinocyte differentiation response to wounding positive regulation of monocyte differentiation regulation of transcription, DNA-templated cellular response to hypoxia regulation of keratinocyte apoptotic process regulation of keratinocyte proliferation phosphatidylinositol 3-kinase signaling cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus regulation of mRNA 3'-end processing MAPK cascade mRNA processing multicellular organism development nuclear-transcribed mRNA catabolic process, deadenylation-independent decay p38MAPK cascade regulation of mRNA stability protein kinase B signaling cellular response to fibroblast growth factor stimulus regulation of B cell differentiation positive regulation of fat cell differentiation regulation of myoblast differentiation mesendoderm development mRNA transport 3'-UTR-mediated mRNA destabilization cellular response to cAMP cellular response to peptide hormone stimulus cellular response to salt stress regulation of stem cell proliferation cellular response to raffinose positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay negative regulation of mitotic cell cycle phase transition transport regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 677 12192 Ensembl ENSG00000185650 ENSMUSG00000021127 UniProt Q07352 P23950 RefSeq (mRNA) NM_004926 NM_001244698 NM_001244701 NM_007564 RefSeq (protein) NP_001231627 NP_001231630 NP_004917 NP_031590 Location (UCSC) Chr 14: 68.79 – 68.8 Mb Chr 12: 80.15 – 80.16 Mb PubMed search
Wikidata
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Function

This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This RNA binding protein most likely functions in regulating the response to growth factors.

ZFP36L1 can degrade transcripts of numerous components of senescence-associated secretory phenotype (SASP) factors.

Interactions

ZFP36L1 has been shown to interact with MAPK14.

Further reading

• Hodson DJ, Janas ML, Galloway A, Bell SE, Andrews S, Li CM, Pannell R, Siebel CW, MacDonald HR, De Keersmaecker K, Ferrando AA, Grutz G, Turner M (August 2010). "Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia". Nat. Immunol. 11 (8): 717–24. doi:10.1038/ni.1901. PMC 2953641. PMID 20622884.
• Bell SE, Sanchez MJ, Spasic-Boskovic O, Santalucia T, Gambardella L, Burton GJ, Murphy JJ, Norton JD, Clark AR, Turner M (November 2006). "The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression". Dev. Dyn. 235 (11): 3144–55. doi:10.1002/dvdy.20949. PMID 17013884.
• Barnard RC, Pascall JC, Brown KD, McKay IA, Williams NS, Bustin SA (July 1993). "Coding sequence of ERF-1, the human homologue of Tis11b/cMG1, members of the Tis11 family of early response genes". Nucleic Acids Res. 21 (15): 3580. doi:10.1093/nar/21.15.3580. PMC 331466. PMID 8346037.
• Maclean KN, See CG, McKay IA, Bustin SA (November 1995). "The human immediate early gene BRF1 maps to chromosome 14q22-q24". Genomics. 30 (1): 89–90. doi:10.1006/geno.1995.0014. PMID 8595910.
• Ning ZQ, Norton JD, Li J, Murphy JJ (October 1996). "Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36". Eur. J. Immunol. 26 (10): 2356–63. doi:10.1002/eji.1830261013. PMID 8898945. S2CID 25669421.
• Blackshear PJ, Phillips RS, Vazquez-Matias J, Mohrenweiser H (2003). "Polymorphisms in the genes encoding members of the tristetraprolin family of human tandem CCCH zinc finger proteins". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 75: 43–68. doi:10.1016/S0079-6603(03)75002-8. ISBN 9780125400756. PMID 14604009.
• Reppe S, Olstad OK, Rian E, Gautvik VT, Gautvik KM, Jemtland R (November 2004). "Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells". Biochem. Biophys. Res. Commun. 324 (1): 218–23. doi:10.1016/j.bbrc.2004.09.030. PMID 15465005.
• Ciais D, Cherradi N, Bailly S, Grenier E, Berra E, Pouyssegur J, Lamarre J, Feige JJ (November 2004). "Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b". Oncogene. 23 (53): 8673–80. doi:10.1038/sj.onc.1207939. PMID 15467755.