ZC3HAV1

Zinc finger CCCH-type antiviral protein 1 is a protein that in humans is encoded by the ZC3HAV1 gene.

ZC3HAV1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2X5Y, 4X52
Identifiers
Aliases	ZC3HAV1, ARTD13, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2, zinc finger CCCH-type containing, antiviral 1
External IDs	OMIM: 607312; MGI: 1926031; HomoloGene: 10585; GeneCards: ZC3HAV1; OMA:ZC3HAV1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q34 Start 139,043,515 bp End 139,132,122 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 B1|6 17.72 cM Start 38,282,221 bp End 38,331,538 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone endothelial cell visceral pleura blood Epithelium of choroid plexus parietal pleura jejunal mucosa pancreatic ductal cell superficial temporal artery bronchial epithelial cell Top expressed in Paneth cell endothelial cell of lymphatic vessel mesenteric lymph nodes blood granulocyte cumulus cell transitional epithelium of urinary bladder spleen hair follicle bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding protein binding RNA binding cadherin binding NAD+ ADP-ribosyltransferase activity NAD+ binding protein ADP-ribosylase activity Cellular component cytoplasm nucleus cytosol Biological process positive regulation of interferon-alpha production immune system process response to virus positive regulation of mRNA catabolic process negative regulation of viral genome replication positive regulation of RIG-I signaling pathway defense response to virus positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of interferon-beta production protein poly-ADP-ribosylation protein ADP-ribosylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56829 78781 Ensembl ENSG00000105939 ENSMUSG00000029826 UniProt Q7Z2W4 Q3UPF5 RefSeq (mRNA) NM_020119 NM_024625 NM_001363491 NM_028421 NM_028864 NM_001347122 RefSeq (protein) NP_064504 NP_078901 NP_001350420 NP_001334051 NP_082697 NP_083140 Location (UCSC) Chr 7: 139.04 – 139.13 Mb Chr 6: 38.28 – 38.33 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and at least four isoform variants have been described.

Mechanism of zinc-finger antiviral protein (ZAP) recognition of specific target RNA, and the process by which ZAP coordinates downstream RNA degradation (right). ZAP-RNA complex protein ribbon diagram (left).

Further reading

• Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Bick MJ, Carroll JW, Gao G, et al. (2003). "Expression of the zinc-finger antiviral protein inhibits alphavirus replication". J. Virol. 77 (21): 11555–62. doi:10.1128/JVI.77.21.11555-11562.2003. PMC 229374. PMID 14557641.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• MacDonald MR, Machlin ES, Albin OR, Levy DE (2007). "The zinc finger antiviral protein acts synergistically with an interferon-induced factor for maximal activity against alphaviruses". J. Virol. 81 (24): 13509–18. doi:10.1128/JVI.00402-07. PMC 2168828. PMID 17928353.