WRNIP1

ATPase WRNIP1 is an enzyme that is encoded by the WRNIP1 gene in humans. The protein is a member of AAA ATPase family.

WRNIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3VHS, 3VHT
Identifiers
Aliases	WRNIP1, WHIP, bA420G6.2, Werner helicase interacting protein 1, WRN helicase interacting protein 1, CFAP93, FAP93
External IDs	OMIM: 608196; MGI: 1926153; HomoloGene: 10592; GeneCards: WRNIP1; OMA:WRNIP1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p25.2 Start 2,765,393 bp End 2,786,952 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A3.2 Start 32,986,021 bp End 33,006,592 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii skin of arm internal globus pallidus cerebellar hemisphere right hemisphere of cerebellum anterior pituitary ventricular zone cerebellar vermis body of pancreas myocardium of left ventricle Top expressed in habenula vestibular membrane of cochlear duct ventromedial nucleus supraoptic nucleus dentate gyrus of hippocampal formation granule cell Paneth cell dorsomedial hypothalamic nucleus Gonadal ridge endocardial cushion anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding ATPase activity protein binding hydrolase activity ATP binding metal ion binding identical protein binding enzyme activator activity single-stranded DNA helicase activity Cellular component perinuclear region of cytoplasm membrane nucleus cytoplasm replisome Biological process DNA replication DNA synthesis involved in DNA repair regulation of DNA-dependent DNA replication initiation DNA repair cellular response to DNA damage stimulus immune system process DNA-dependent DNA replication regulation of DNA repair DNA recombination DNA replication, Okazaki fragment processing positive regulation of catalytic activity innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56897 78903 Ensembl ENSG00000124535 ENSMUSG00000021400 UniProt Q96S55 Q91XU0 RefSeq (mRNA) NM_020135 NM_130395 NM_030215 RefSeq (protein) NP_064520 NP_569079 NP_084491 Location (UCSC) Chr 6: 2.77 – 2.79 Mb Chr 13: 32.99 – 33.01 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Werner's syndrome is a rare autosomal recessive disorder characterized by premature aging. The protein encoded by this gene interacts with the N-terminal portion of Werner protein containing the exonuclease domain. This protein shows homology to replication factor C family proteins, and is conserved from E. coli to human. Studies in yeast suggest that this gene may influence the aging process. Two transcript variants encoding different isoforms have been isolated for this gene.

Interactions

WRNIP1 has been shown to interact with Werner syndrome ATP-dependent helicase.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Tsurimoto T, Shinozaki A, Yano M, et al. (2005). "Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta". Genes Cells. 10 (1): 13–22. doi:10.1111/j.1365-2443.2004.00812.x. PMID 15670210. S2CID 24977510.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Bish RA, Myers MP (2007). "Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain". J. Biol. Chem. 282 (32): 23184–93. doi:10.1074/jbc.M701042200. PMID 17550899.

External links

• FactorBook WHIP