Victor Muñoz is a biochemist whose focus has been on protein folding and design. He provided experimental evidence for a mechanism of protein folding called as "downhill folding".[1] He has pioneered various computational and experimental techniques to study this mechanism as well as to gain insights into the general process of protein folding.
Prof. Muñoz has used different standard biophysical techniques, such as Nuclear Magnetic Resonance (NMR), to unravel the downhill folding mechanism at an atom-by-atom level,[2] using ultrafast laser temperature jump (T-jump) experiments for studying the kinetics of very fast folding proteins (microsecond timescales), driving Fluorescence Spectroscopy techniques (FRET) at single molecule level to study processes with fast dynamics[3] as well as developing various computational models for quantitative analysis of a multitude of protein folding experimental data from various equilibrium and kinetics experiments.[4][5][6] He has also been involved in design and engineering of proteins towards desired properties and functionalities. He has coordinated a consortium of researchers from Spain, "PRODESTECH", for tailoring enzymes, therapeutics and synthetic macromolecular devices from designed proteins.
Dr. Muñoz has been a member of the faculty of the Department of Chemistry & Biochemistry at the University of Maryland since 2000 and has won the Searle Scholar Award, and the David and Lucille Packard Fellowship for Science and Engineering. He moved back to Spain in 2007 as a professor at the Center for Biological Investigations (CIB) of the Spanish Research Council (CSIC) at Madrid. He was elected to the European Molecular Biology Organization in 2009.
References
edit- ^ Garcia-Mira, M. M.; Sadqi, M.; Fischer, N.; Sanchez-Ruiz, J.; Muñoz, V. (2002). "Experimental Identification of Downhill Protein Folding". Science. 298 (5601): 2191–2195. Bibcode:2002Sci...298.2191G. doi:10.1126/science.1077809. PMID 12481137. S2CID 14856515.
- ^ Sadqi, M.; Fushman, D.; Muñoz, V. (2006). "Atom-by-atom analysis of global downhill protein folding". Nature. 442 (7100): 317–321. Bibcode:2006Natur.442..317S. doi:10.1038/nature04859. PMID 16799571. S2CID 4355553.
- ^ Campos, L. A.; Liu, J.; Wang, X.; Ramanathan, R.; English, D. S.; Muñoz, V. (2011). "A photoprotection strategy for microsecond-resolution single-molecule fluorescence spectroscopy". Nature Methods. 8 (2): 143–146. doi:10.1038/nmeth.1553. PMID 21217750. S2CID 19763021.
- ^ Naganathan, A. N.; Munoz, V. (2010). "Insights into protein folding mechanisms from large scale analysis of mutational effects". Proceedings of the National Academy of Sciences. 107 (19): 8611–8616. Bibcode:2010PNAS..107.8611N. doi:10.1073/pnas.1000988107. PMC 2889297. PMID 20418505.
- ^ Li, P.; Oliva, F. Y.; Naganathan, A. N.; Munoz, V. (2008). "Dynamics of one-state downhill protein folding". Proceedings of the National Academy of Sciences. 106 (1): 103–108. Bibcode:2009PNAS..106..103L. doi:10.1073/pnas.0802986106. PMC 2629219. PMID 19118204.
- ^ Naganathan, A. N.; Doshi, U.; Fung, A.; Sadqi, M.; Muñoz, V. (2006). "Dynamics, Energetics, and Structure in Protein Folding†". Biochemistry. 45 (28): 8466–8475. doi:10.1021/bi060643c. PMC 2546509. PMID 16834320.
External links
edit- Prof. Victor Muñoz Homepage
- The Muñoz Group Webpage
- Elected as EMBO Member, 2009
- 2002 Searle Scholar Award, USA
- 2001 David and Lucille Packard Fellowship for Science and Engineering, USA
- "Protein Folding, Misfolding and Aggregation", RSC Publishing
- PRODESTECH - Protein Design Technologies Consortium
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