Vardinogiannis (Greek: Βαρδινογιάννης) is a Greek surname. Notable people with the surname include:
- Vardis Vardinogiannis (born 1931), Greek oil and shipping tycoon
- Yiorgos Vardinogiannis (born 1936), Greek shipping magnate
- Marianna Vardinoyannis, wife of Vardis Vardinogiannis
- Giannis Vardinogiannis (born 1962), Greek entrepreneur