VARS

For other uses, see Vars (disambiguation).

Valyl-tRNA synthetase is an enzyme that in humans is encoded by the VARS gene.

VARS1
Identifiers
Aliases	VARS1, VARS, NDMSCA, valyl-tRNA synthetase 1, G7A, VARS2, valyl-tRNA synthetase
External IDs	OMIM: 192150; MGI: 90675; HomoloGene: 4587; GeneCards: VARS1; OMA:VARS1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.33 Start 31,777,518 bp End 31,795,752 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 B1|17 18.54 cM Start 35,219,963 bp End 35,235,298 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis islet of Langerhans pituitary gland ganglionic eminence appendix anterior pituitary stromal cell of endometrium gastrocnemius muscle muscle tissue Top expressed in spermatid ventricular zone tail of embryo seminiferous tubule epiblast yolk sac spermatocyte lip tibiofemoral joint otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function aminoacyl-tRNA ligase activity nucleotide binding ligase activity protein binding ATP binding aminoacyl-tRNA editing activity valine-tRNA ligase activity Cellular component cytoplasm cytosol Biological process tRNA aminoacylation for protein translation protein biosynthesis valyl-tRNA aminoacylation aminoacyl-tRNA metabolism involved in translational fidelity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7407 22321 Ensembl ENSG00000226589 ENSG00000096171 ENSG00000231945 ENSG00000227686 ENSG00000204394 ENSG00000224264 ENSG00000231116 ENSMUSG00000007029 UniProt P26640 Q9Z1Q9 RefSeq (mRNA) NM_006295 NM_011690 RefSeq (protein) NP_006286 NP_006286.1 NP_035820 Location (UCSC) Chr 6: 31.78 – 31.8 Mb Chr 17: 35.22 – 35.24 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex.

See also

• Valine-tRNA ligase

Further reading

• Hsieh SL, Campbell RD (September 1991). "Evidence that gene G7a in the human major histocompatibility complex encodes valyl-tRNA synthetase". The Biochemical Journal. 278 (3): 809–16. doi:10.1042/bj2780809. PMC 1151418. PMID 1898367.
• Sargent CA, Dunham I, Campbell RD (August 1989). "Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region". The EMBO Journal. 8 (8): 2305–12. doi:10.1002/j.1460-2075.1989.tb08357.x. PMC 401163. PMID 2477242.
• Bec G, Kerjan P, Zha XD, Waller JP (December 1989). "Valyl-tRNA synthetase from rabbit liver. I. Purification as a heterotypic complex in association with elongation factor 1". The Journal of Biological Chemistry. 264 (35): 21131–7. doi:10.1016/S0021-9258(19)30056-0. PMID 2556394.
• Wolfson AD, Orlovsky AF, Gladilin KL (October 1988). "Mammalian valyl-tRNA synthetase forms a complex with the first elongation factor". FEBS Letters. 238 (2): 262–4. Bibcode:1988FEBSL.238..262M. doi:10.1016/0014-5793(88)80492-7. PMID 3169261. S2CID 45934458.
• Bec G, Kerjan P, Waller JP (January 1994). "Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation". The Journal of Biological Chemistry. 269 (3): 2086–92. doi:10.1016/S0021-9258(17)42139-9. PMID 8294461.
• Vilalta A, Donovan D, Wood L, Vogeli G, Yang DC (January 1993). "Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase". Gene. 123 (2): 181–6. doi:10.1016/0378-1119(93)90122-J. PMID 8428657.
• Motorin Y (May 1996). "Two human valyl-tRNA synthetase-encoding cDNA sequences deposited in GenBank display extensive differences". Gene. 170 (2): 289–91. doi:10.1016/0378-1119(96)84699-3. PMID 8666263.
• Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L (December 2003). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Research. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Jiang S, Wolfe CL, Warrington JA, Norcum MT (November 2005). "Three-dimensional reconstruction of the valyl-tRNA synthetase/elongation factor-1H complex and localization of the delta subunit". FEBS Letters. 579 (27): 6049–54. Bibcode:2005FEBSL.579.6049J. doi:10.1016/j.febslet.2005.09.062. PMID 16229838. S2CID 83645345.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.