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The uxuA RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] uxuA motif RNAs are found in the bacterial genus Vibrio.
| uxuA | |
|---|---|
 Consensus secondary structure and sequence conservation of uxuA RNA | |
| Identifiers | |
| Symbol | uxuA |
| Rfam | RF03061 |
| Other data | |
| RNA type | Gene; sRNA |
| SO | SO:0001263 |
| PDB structures | PDBe |
uxuA RNAs occur upstream of genes that encode mannonate dehydratase, which functions as part of the catabolism of glucuronate. This gene association could suggest that uxuA RNAs operate as cis-regulatory elements to control expression of the mannonate dehydratase genes. However, since the RNAs are found in relatively closely related organisms, it is possible that the apparent gene association arose by chance. Therefore, uxuA RNAs might also function in trans as small RNAs.
References
edit- ^ Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. doi:10.1093/nar/gkx699. PMC 5737381. PMID 28977401.
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