Boatswi
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Your submission at Articles for creation: Vincent Cryns (September 19)
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Your submission at Articles for creation: Vincent Cryns has been accepted
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Onel5969 TT me 19:41, 27 September 2015 (UTC)Your submission at Articles for creation: Richard Page (Professor) has been accepted
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Hermera34 (talk) 15:51, 30 September 2015 (UTC)Your submission at Articles for creation: Sanjay Asthana (October 14)
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References
editThank you for contributing to Wikipedia. Remember that when adding content about health, please only use high-quality reliable sources as references. We typically use review articles, major textbooks and position statements of national or international organizations (There are several kinds of sources that discuss health: here is how the community classifies them and uses them). WP:MEDHOW walks you through editing step by step. A list of resources to help edit health content can be found here. The edit box has a built-in citation tool to easily format references based on the PMID or ISBN. We also provide style advice about the structure and content of medicine-related encyclopedia articles. The welcome page is another good place to learn about editing the encyclopedia. If you have any questions, please feel free to drop me a note. Jytdog (talk) 16:26, 15 October 2017 (UTC)
Your submission at Articles for creation: Holly Van Remmen (June 19)
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Your submission at Articles for creation: Holly Van Remmen has been accepted
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asilvering (talk) 21:39, 25 June 2023 (UTC)1000+ refs to isoleu in 2023
editYour papers are so crucial that they beat out 78,000+ papers published on this amino acid. Ref spamming (similar references) eventually results in those refs being removed. Diverse, high quality review-ish references are recommended. Here are the usually guidelines for established topics (which isoleucine certainly is): WP:SECONDARY and WP:TERTIARY.--Smokefoot (talk) 18:24, 26 November 2023 (UTC)
- thank you for pointing out the importance of secondary and tertiary references for established topics, I was not aware of those guidelines but they make sense. Boatswi (talk) 15:34, 30 November 2023 (UTC)
Check it out
editRefs added to mTOR:
June 2016 [1]
5 March 2016
[4][5][6][7]Cite error: A <ref>
tag is missing the closing </ref>
(see the help page).[8][9][10][11][12][13]
- ^ Kennedy, Brian K.; Lamming, Dudley W. (2016-06-14). "The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging". Cell Metabolism. 23 (6): 990–1003. doi:10.1016/j.cmet.2016.05.009. ISSN 1932-7420. PMC 4910876. PMID 27304501.
- ^ Arriola Apelo, Sebastian I.; Pumper, Cassidy P.; Baar, Emma L.; Cummings, Nicole E.; Lamming, Dudley W. (2016-04-18). "Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice". The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. doi:10.1093/gerona/glw064. ISSN 1758-535X. PMID 27091134.
- ^ Popovich, Irina G.; Anisimov, Vladimir N.; Zabezhinski, Mark A.; Semenchenko, Anna V.; Tyndyk, Margarita L.; Yurova, Maria N.; Blagosklonny, Mikhail V. (2014-05-01). "Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin". Cancer Biology & Therapy. 15 (5): 586–592. doi:10.4161/cbt.28164. ISSN 1555-8576. PMC 4026081. PMID 24556924.
- ^ Mitra A, Luna JI, Marusina AI, Merleev A, Kundu-Raychaudhuri S, Fiorentino D, Raychaudhuri SP, Maverakis E (2015). "Dual mTOR Inhibition Is Required to Prevent TGF-β-Mediated Fibrosis: Implications for Scleroderma". J Invest Dermatol. 135 (11): 2873–6. doi:10.1038/jid.2015.252. PMC 4640976. PMID 26134944.
{{cite journal}}
: CS1 maint: multiple names: authors list (link) - ^ Wu JJ, Liu J, Chen EB, Wang JJ, Cao L, Narayan N, Fergusson MM, Rovira II, Allen M, Springer DA, Lago CU, Zhang S, DuBois W, Ward T, deCabo R, Gavrilova O, Mock B, Finkel T (Sep 2013). "Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression". Cell Reports. 4 (5): 913–20. doi:10.1016/j.celrep.2013.07.030. PMC 3784301. PMID 23994476.
- ^ Nojima A, Yamashita M, Yoshida Y, Shimizu I, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Ishii N, Minamino T (2013-01-01). "Haploinsufficiency of akt1 prolongs the lifespan of mice". PLOS ONE. 8 (7): e69178. doi:10.1371/journal.pone.0069178. PMC 3728301. PMID 23935948.
{{cite journal}}
: CS1 maint: unflagged free DOI (link) - ^ Baar, Emma L.; Carbajal, Kathryn A.; Ong, Irene M.; Lamming, Dudley W. (2016-02-01). "Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice". Aging Cell. 15 (1): 155–166. doi:10.1111/acel.12425. ISSN 1474-9726. PMC 4717274. PMID 26695882.
- ^ Guertin, David A.; Stevens, Deanna M.; Thoreen, Carson C.; Burds, Aurora A.; Kalaany, Nada Y.; Moffat, Jason; Brown, Michael; Fitzgerald, Kevin J.; Sabatini, David M. (2006-12-01). "Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1". Developmental Cell. 11 (6): 859–871. doi:10.1016/j.devcel.2006.10.007. ISSN 1534-5807. PMID 17141160.
- ^ Gu, Yanyun; Lindner, Jill; Kumar, Anil; Yuan, Weiping; Magnuson, Mark A. (2011-03-01). "Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size". Diabetes. 60 (3): 827–837. doi:10.2337/db10-1194. ISSN 1939-327X. PMC 3046843. PMID 21266327.
- ^ Lamming, Dudley W.; Demirkan, Gokhan; Boylan, Joan M.; Mihaylova, Maria M.; Peng, Tao; Ferreira, Jonathan; Neretti, Nicola; Salomon, Arthur; Sabatini, David M. (2014-01-01). "Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)". FASEB journal: official publication of the Federation of American Societies for Experimental Biology. 28 (1): 300–315. doi:10.1096/fj.13-237743. ISSN 1530-6860. PMC 3868844. PMID 24072782.
{{cite journal}}
: CS1 maint: unflagged free DOI (link) - ^ Kumar, Anil; Lawrence, John C.; Jung, Dae Young; Ko, Hwi Jin; Keller, Susanna R.; Kim, Jason K.; Magnuson, Mark A.; Harris, Thurl E. (2010-06-01). "Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism". Diabetes. 59 (6): 1397–1406. doi:10.2337/db09-1061. ISSN 1939-327X. PMC 2874700. PMID 20332342.
- ^ Lamming, Dudley W.; Ye, Lan; Katajisto, Pekka; Goncalves, Marcus D.; Saitoh, Maki; Stevens, Deanna M.; Davis, James G.; Salmon, Adam B.; Richardson, Arlan (2012-03-30). "Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity". Science (New York, N.Y.). 335 (6076): 1638–1643. doi:10.1126/science.1215135. ISSN 1095-9203. PMC 3324089. PMID 22461615.
- ^ Lamming, Dudley W.; Mihaylova, Maria M.; Katajisto, Pekka; Baar, Emma L.; Yilmaz, Omer H.; Hutchins, Amanda; Gultekin, Yetis; Gaither, Rachel; Sabatini, David M. (2014-10-01). "Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan". Aging Cell. 13 (5): 911–917. doi:10.1111/acel.12256. ISSN 1474-9726. PMC 4172536. PMID 25059582.
- ^ Miller, Richard A.; Harrison, David E.; Astle, Clinton M.; Fernandez, Elizabeth; Flurkey, Kevin; Han, Melissa; Javors, Martin A.; Li, Xinna; Nadon, Nancy L. (2014-06-01). "Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction". Aging Cell. 13 (3): 468–477. doi:10.1111/acel.12194. ISSN 1474-9726. PMC 4032600. PMID 24341993.
- ^ Fok, Wilson C.; Chen, Yidong; Bokov, Alex; Zhang, Yiqiang; Salmon, Adam B.; Diaz, Vivian; Javors, Martin; Wood, William H.; Zhang, Yongqing (2014-01-01). "Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome". PloS One. 9 (1): e83988. doi:10.1371/journal.pone.0083988. ISSN 1932-6203. PMC 3883653. PMID 24409289.
{{cite journal}}
: CS1 maint: unflagged free DOI (link) - ^ Johnston, Olwyn; Rose, Caren L.; Webster, Angela C.; Gill, John S. (2008-07-01). "Sirolimus is associated with new-onset diabetes in kidney transplant recipients". Journal of the American Society of Nephrology: JASN. 19 (7): 1411–1418. doi:10.1681/ASN.2007111202. ISSN 1533-3450. PMC 2440303. PMID 18385422.
- ^ Trelinska, Joanna; Dachowska, Iwona; Kotulska, Katarzyna; Fendler, Wojciech; Jozwiak, Sergiusz; Mlynarski, Wojciech (2015-04-01). "Complications of mammalian target of rapamycin inhibitor anticancer treatment among patients with tuberous sclerosis complex are common and occasionally life-threatening". Anti-Cancer Drugs. 26 (4): 437–442. doi:10.1097/CAD.0000000000000207. ISSN 1473-5741. PMID 25719621.
- ^ Lamming, Dudley W.; Ye, Lan; Astle, Clinton M.; Baur, Joseph A.; Sabatini, David M.; Harrison, David E. (2013-08-01). "Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive". Aging Cell. 12 (4): 712–718. doi:10.1111/acel.12097. ISSN 1474-9726. PMC 3727050. PMID 23648089.
- ^ Arriola Apelo, Sebastian I.; Neuman, Joshua C.; Baar, Emma L.; Syed, Faizan A.; Cummings, Nicole E.; Brar, Harpreet K.; Pumper, Cassidy P.; Kimple, Michelle E.; Lamming, Dudley W. (2015-10-13). "Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system". Aging Cell. doi:10.1111/acel.12405. ISSN 1474-9726. PMID 26463117.
- ^ Baar, Emma L.; Carbajal, Kathryn A.; Ong, Irene M.; Lamming, Dudley W. (2016-02-01). "Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice". Aging Cell. 15 (1): 155–166. doi:10.1111/acel.12425. ISSN 1474-9726. PMC 4717274. PMID 26695882.
- ^ Caron, Alexandre; Richard, Denis; Laplante, Mathieu (2015-01-01). "The Roles of mTOR Complexes in Lipid Metabolism". Annual Review of Nutrition. 35: 321–348. doi:10.1146/annurev-nutr-071714-034355. ISSN 1545-4312. PMID 26185979.