In cellular biology, eukaryotic transcription is the production of a primary transcript from DNA by RNA polymerases. Regulation of transcription elongation by elongation factors is necessary to continue transcription and reduce the probability of dissociation of RNA polymerase II from the transcribed gene.[1][2] RNA polymerase II most frequently pauses at promoter-proximal regions, where transcription elongation factors such as P-TEFb and its associated complexes, SII, elongin, ELL, NELF, DSIF, and PAF1 may modulate its activity.[2][3]
Early detection of RNA polymerase II pausing at a promoter-proximal region between -12 and + 65 nucleotides was seen in the Hsp70 gene in cells not in heat shock, thus possibly serving to regulate transcription.[2][4]
References
edit- ^ Cite error: The named reference
MBOCwas invoked but never defined (see the help page). - ^ a b c Chen, Fei Xavier; Smith, Edwin R.; Shilatifard, Ali (2018). "Born to run: control of transcription elongation by RNA polymerase II". Nature Reviews Molecular Cell Biology. 19 (7): 464–478. doi:10.1038/s41580-018-0010-5. ISSN 1471-0080.
- ^ "PAF1 - RNA polymerase II-associated factor 1 homolog - Homo sapiens (Human) - PAF1 gene & protein". www.uniprot.org. Retrieved 2021-09-08.
- ^ Gilmour, D S; Lis, J T (1986). "RNA polymerase II interacts with the promoter region of the noninduced hsp70 gene in Drosophila melanogaster cells". Molecular and Cellular Biology. 6 (11): 3984–3989. ISSN 0270-7306. PMID 3099167.