| County | Location | mi | km | Destinations | Notes |
|---|---|---|---|---|---|
| Monroe | | 0.00 | 0.00 |     I-255 west / US 50 west – Mehlville | Missouri state line |
| |   IL 3 south | Southern end of IL 3 concurrency | |||
| St. Clair | |  IL 3 north – Cahokia | Northern end of IL 3 concurrency | ||
| |  IL 157 | ||||
| East St. Louis | Lua error in Module:Jct at line 204: attempt to concatenate local 'link' (a nil value). | ||||
  I-64 west / I-255 north | Northern end of I–255 concurrency; western end of I–64 concurrency | ||||
| Fairview Heights | IL 157 | ||||
 IL 159 | |||||
| O'Fallon |  I-64 east – Mt. Vernon | Eastern end of I–64 concurrency | |||
| Lebanon |  IL 4 south – Mascoutah | Southern end of IL 4 concurrency | |||
| IL 4 north | Northern end of IL 4 concurrency | ||||
| Clinton | Trenton |  IL 160 | |||
| Carlyle |  IL 127 north | Northern end of IL 127 concurrency | |||
| IL 127 south | Southern end of IL 127 concurrency | ||||
| Marion | Sandoval |  US 51 – Centralia, Vandalia | |||
| Salem |  I-55 – Mt. Vernon, Effingham | ||||
 IL 37 – Mt. Vernon, Effingham | |||||
| Clay | Flora |  US 45 north – Effingham | Western end of US 45 concurrency | ||
| US 45 south – Fairfield | Eastern end of US 45 concurrency | ||||
| Richland | |   IL 250 east | Western terminus of IL 250 | ||
| Olney |  IL 130 | ||||
| IL 250 west | Western end of IL 250 concurrency | ||||
| Lawrence | | IL 250 east | Eastern end of IL 250 concurrency | ||
| Lawrenceville |  US 50 Bus. east | Western terminus of US 50 BUS | |||
 IL 1 – Lawrenceville, Marshall | |||||
| US 50 Bus. west | Eastern terminus of US 50 BUS | ||||
| |  IL 33 north | Southern terminus of IL 33 | |||
| | US 50 east | Indiana state line | |||
| 1.000 mi = 1.609 km; 1.000 km = 0.621 mi | |||||
