"Uptown Girl" is a 1983 song by Billy Joel.
Uptown Girl(s) may also refer to:
- Uptown Girl (EP), by Mirani, 2021
- "Uptown Girl", a 1981 song by Leif Garrett
- "Uptown Girl", a season 8 episode of Degrassi: The Next Generation
- Uptown Girls, a 2003 American film
- Uptown Girls (group), an American music group active during the 1980s