Ulobetasol

Ulobetasol
Clinical data
Trade names	Ultravate
Other names	(6S,8S,9S,10S,11S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one, halobetasol (USAN US)
AHFS/Drugs.com	Professional Drug Facts
MedlinePlus	a601060
ATC code	D07AC21 (WHO) ; D05AX55 (WHO) (combination with tazarotene);
Identifiers
	IUPAC name (6α,11β,16β)-21-Chloro-6,9-difluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione;
CAS Number	98651-66-2 ;
PubChem CID	5311167;
ChemSpider	4470691 ;
UNII	9P6159HM7T;
KEGG	D08660 ;
ChEMBL	ChEMBL1201360 ;
CompTox Dashboard (EPA)	DTXSID60243759 ;
Chemical and physical data
Formula	C22H27ClF2O4
Molar mass	428.90 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES ClCC(=O)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@@H]3C)C)C;
	InChI InChI=1S/C22H27ClF2O4/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1 ; Key:LEHFPXVYPMWYQD-XHIJKXOTSA-N ;
	(what is this?) (verify)

Ulobetasol (INN) or halobetasol (USAN) is a corticosteroid used to treat psoriasis.^[1]^[2] It is a class I corticosteroid under the US classification and a group III corticosteroid under international classification, the most potent group of such drugs.^[3]^[4]

Ulobetasol propionate is usually supplied as a 0.05% topical cream.^[1] Ulobetasol is the strongest topical steroid available.^{[citation needed]} It is also sold with tazarotene with 0.01% halobetasol and 0.045% tazarotene as a lotion branded as Duobrii (Bausch Health).

It is available as a generic medication.^[5]

References

^ ^a ^b "Ultravate product monograph" (PDF). Retrieved 2021-01-04.
^ DrugBank DB00596 . Retrieved 2020-01-04.
^ Pearce DJ, Spencer L, Hu J, Balkrishnan R, Fleischer AB, Feldman SR (July 2004). "Class I topical corticosteroid use by psoriasis patients in an academic practice". The Journal of Dermatological Treatment. 15 (4): 235–8. doi:10.1080/09546630410033745. PMID 15764038. S2CID 2757493.
^ ATC code D07AC21 (WHO). Retrieved 2020-01-04.
^ "Ulobetasol international". Drugs.com. 10 August 2020. Retrieved 15 August 2020.

External links

"Halobetasol". Drug Information Portal. U.S. National Library of Medicine.
"Halobetasol propionate". Drug Information Portal. U.S. National Library of Medicine.
halobetasol at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This dermatologic drug article is a stub. You can help Wikipedia by expanding it.

[monograph-1] "Ultravate product monograph" (PDF). Retrieved 2021-01-04.

[2] DrugBank DB00596 . Retrieved 2020-01-04.

[3] Pearce DJ, Spencer L, Hu J, Balkrishnan R, Fleischer AB, Feldman SR (July 2004). "Class I topical corticosteroid use by psoriasis patients in an academic practice". The Journal of Dermatological Treatment. 15 (4): 235–8. doi:10.1080/09546630410033745. PMID 15764038. S2CID 2757493.

[4] ATC code D07AC21 (WHO). Retrieved 2020-01-04.

[5] "Ulobetasol international". Drugs.com. 10 August 2020. Retrieved 15 August 2020.

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