USS Serapis may refer to the following ships operated by the United States Navy:
- Serapis, was a British frigate known as HMS Serapis captured by John Paul Jones and the crew of Bonhomme Richard in 1779. She was later sold to France.
- USS Serapis (1864), was a steam sloop, authorized in 1864 but never fully completed
- USS Serapis (IX-213), was a single-screw tanker built in 1921 and originally named District of Columbia.
This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.