USS Macdonough may refer to the following ships of the United States Navy:
- USS Macdonough (DD-9), was an early destroyer, launched in 1900 and served until 1919
- USS Macdonough (DD-331), was a Clemson-class destroyer, launched in 1920 and served until 1930
- USS Macdonough (DD-351), was a Farragut-class destroyer, launched in 1934 and served through World War II until 1945
- USS Macdonough (DDG-39), was a Farragut-class guided missile frigate (destroyer leader), launched in 1959 and served until 1992
See also
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This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.