USP2

Ubiquitin carboxyl-terminal hydrolase 2 is an enzyme that in humans is encoded by the USP2 gene.

USP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HD5, 2IBI, 3NHE, 3V6C, 3V6E
Identifiers
Aliases	USP2, UBP41, USP9, ubiquitin specific peptidase 2
External IDs	OMIM: 604725; MGI: 1858178; HomoloGene: 3098; GeneCards: USP2; OMA:USP2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q23.3 Start 119,355,215 bp End 119,381,711 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A5.1 Start 44,067,021 bp End 44,095,627 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle left testis sperm apex of heart right testis secondary oocyte Skeletal muscle tissue of rectus abdominis left ventricle right auricle Top expressed in seminiferous tubule plantaris muscle muscle of thigh extensor digitorum longus muscle skeletal muscle tissue vestibular membrane of cochlear duct neural layer of retina gastrocnemius muscle ankle soleus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cysteine-type peptidase activity metal ion binding peptidase activity protein binding identical protein binding cysteine-type endopeptidase activity hydrolase activity ubiquitin protein ligase binding cyclin binding thiol-dependent deubiquitinase Cellular component cytoplasm centrosome cell cortex perinuclear region of cytoplasm nucleus nucleoplasm membrane Biological process ubiquitin-dependent protein catabolic process rhythmic process muscle organ development protein stabilization positive regulation of mitotic cell cycle negative regulation of transcription by RNA polymerase II circadian regulation of gene expression proteolysis circadian behavior cell cycle entrainment of circadian clock by photoperiod locomotor rhythm protein deubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9099 53376 Ensembl ENSG00000036672 ENSMUSG00000032010 UniProt O75604 O88623 RefSeq (mRNA) NM_001243759 NM_004205 NM_171997 NM_016808 NM_198091 NM_198092 RefSeq (protein) NP_001230688 NP_004196 NP_741994 NP_058088 NP_932759 NP_932760 NP_001394747 NP_001394748 NP_001394749 NP_001394750 NP_001394751 NP_001394752 NP_001394753 NP_001394754 NP_001394755 NP_001394756 Location (UCSC) Chr 11: 119.36 – 119.38 Mb Chr 9: 44.07 – 44.1 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin (MIM 191339), a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs). Also see USP1 (MIM 603478).[supplied by OMIM]

Further reading

• D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704.
• Baek SH, Choi KS, Yoo YJ, et al. (1997). "Molecular cloning of a novel ubiquitin-specific protease, UBP41, with isopeptidase activity in chick skeletal muscle". J. Biol. Chem. 272 (41): 25560–5. doi:10.1074/jbc.272.41.25560. PMID 9325273.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gewies A, Grimm S (2003). "UBP41 is a proapoptotic ubiquitin-specific protease". Cancer Res. 63 (3): 682–8. PMID 12566314.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Graner E, Tang D, Rossi S, et al. (2004). "The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer". Cancer Cell. 5 (3): 253–61. doi:10.1016/S1535-6108(04)00055-8. PMID 15050917.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Stevenson LF, Sparks A, Allende-Vega N, et al. (2007). "The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2". EMBO J. 26 (4): 976–86. doi:10.1038/sj.emboj.7601567. PMC 1852834. PMID 17290220.