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Tryptophan tryptophylquinone

Tryptophan tryptophylquinone (TTQ)[1] is an enzyme cofactor, generated by posttranslational modification of amino acids within the protein. Methylamine dehydrogenase (MADH), an amine dehydrogenase, requires TTQ for its catalytic function.[2]

Tryptophan tryptophylquinone
Names
IUPAC name
2-Amino-3-[2-[2-amino-3-(2-carboxyethyl)-6,7-dioxo-1H-indol-4-yl]-1H-indol-3-yl]propanoic acid
Identifiers
3D model (JSmol)
MeSH Tryptophan+tryptophylquinone
  • C1=CC=C2C(=C1)C(=C(N2)C3=CC(=O)C(=O)C4=C3C(=C(N4)N)CCC(=O)O)CC(C(=O)O)N
Properties
C22H20N4O6
Molar mass 436.424 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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See also

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References

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  1. ^ Davidson, V. L.; Liu, A. (2012). "Tryptophan tryptophylquinone biosynthesis: A radical approach to posttranslational modification, by Victor L. Davidson1 and Aimin Liu2, on National Center for Biotechnology Information, U.S. National Library of Medicine, published 2012 Jan 28. doi: 10.1016/j.bbapap.2012.01.008". Biochimica et Biophysica Acta. 1824 (11): 1299–1305. doi:10.1016/j.bbapap.2012.01.008. PMC 3432176. PMID 22314272.
  2. ^ Davidson VL, Liu A (2009). "Uncovering novel biochemistry in the mechanism of tryptophan tryptophylquinone cofactor biosynthesis". Curr. Opin. Chem. Biol. 13 (4): 469–474. doi:10.1016/j.cbpa.2009.06.026. PMC 2749888. PMID 19648051.
 

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