Tolibut

Tolibut
Clinical data
ATC code	None;
Identifiers
	IUPAC name 4-Amino-3-(4-methylphenyl)butanoic acid;
CAS Number	28311-38-8 ; 28311-37-7 (HCl);
PubChem CID	49344;
ChemSpider	44852;
UNII	UJ5N9SJ9NL;
CompTox Dashboard (EPA)	DTXSID00951003 ;
Chemical and physical data
Formula	C11H15NO2
Molar mass	193.246 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CC=C(C=C1)C(CC(=O)O)CN;
	InChI InChI=1S/C11H15NO2/c1-8-2-4-9(5-3-8)10(7-12)6-11(13)14/h2-5,10H,6-7,12H2,1H3,(H,13,14); Key:MSZRPURXKHMSFF-UHFFFAOYSA-N;

Tolibut, also known as 3-(p-tolyl)-4-aminobutyric acid (or β-(4-methylphenyl)-GABA), is drug that was developed in Russia. It is an analogue of γ-aminobutyric acid (GABA) and is the 4-methyl analogue of phenibut, and is also an analogue of baclofen where the 4-chloro substitution has been replaced with a 4-methyl substitution. Tolibut has been described as possessing analgesic, tranquilizing, and neuroprotective properties. It is not fully clear as to whether the drug was ever approved or used medically in Russia.^[1]^[2]^[3]^[4]

References

^ Tyurenkov IN, Borodkina LE, Bagmetova VV (September 2012). "Functional aspects of neuroprotective effects of new salts and compositions of baclofen in the convulsive syndrome caused by electroshock". Bulletin of Experimental Biology and Medicine. 153 (5): 710–713. doi:10.1007/s10517-012-1806-5. PMID 23113265. S2CID 767044.
^ Morozov IS, Kovalev GI, Maisov NI, Kovalev GV, Raevskii KS (January 1977). "Effect of analogs of γ -aminobutyric acid on the uptake of [3H]-γ -aminobutyric acid by synaptosomes of the rat brain". Pharmaceutical Chemistry Journal. 11 (1): 10–12. doi:10.1007/BF00779108. S2CID 27281385.
^ Dmitriev AV, Andreev NI (1987). "[The spectrum of analgesic activity of baclofen and tolibut]". Farmakologiia I Toksikologiia (in Russian). 50 (1): 24–27. PMID 3556547.
^ Artem'ev II, Darinskiĭ I, Sologub MI (1992). "[A hypothesis of the possible mechanism of the action of analgesic agents at the neuronal level]". Eksperimental'naia i Klinicheskaia Farmakologiia (in Russian). 55 (1): 16–18. PMID 1363942.

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[TyurenkovBorodkina2012-1] Tyurenkov IN, Borodkina LE, Bagmetova VV (September 2012). "Functional aspects of neuroprotective effects of new salts and compositions of baclofen in the convulsive syndrome caused by electroshock". Bulletin of Experimental Biology and Medicine. 153 (5): 710–713. doi:10.1007/s10517-012-1806-5. PMID 23113265. S2CID 767044.

[Morozov1977-2] Morozov IS, Kovalev GI, Maisov NI, Kovalev GV, Raevskii KS (January 1977). "Effect of analogs of γ -aminobutyric acid on the uptake of [3H]-γ -aminobutyric acid by synaptosomes of the rat brain". Pharmaceutical Chemistry Journal. 11 (1): 10–12. doi:10.1007/BF00779108. S2CID 27281385.

[pmid3556547-3] Dmitriev AV, Andreev NI (1987). "[The spectrum of analgesic activity of baclofen and tolibut]". Farmakologiia I Toksikologiia (in Russian). 50 (1): 24–27. PMID 3556547.

[pmid1363942-4] Artem'ev II, Darinskiĭ I, Sologub MI (1992). "[A hypothesis of the possible mechanism of the action of analgesic agents at the neuronal level]". Eksperimental'naia i Klinicheskaia Farmakologiia (in Russian). 55 (1): 16–18. PMID 1363942.

[1]

[2]

[3]

[4]

Clinical data

ATC code	None
Identifiers
IUPAC name 4-Amino-3-(4-methylphenyl)butanoic acid
CAS Number	28311-38-8 28311-37-7 (HCl)
PubChem CID	49344
ChemSpider	44852
UNII	UJ5N9SJ9NL
CompTox Dashboard (EPA)	DTXSID00951003
Chemical and physical data
Formula	C₁₁H₁₅NO₂
Molar mass	193.246 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=CC=C(C=C1)C(CC(=O)O)CN
InChI InChI=1S/C11H15NO2/c1-8-2-4-9(5-3-8)10(7-12)6-11(13)14/h2-5,10H,6-7,12H2,1H3,(H,13,14) Key:MSZRPURXKHMSFF-UHFFFAOYSA-N

Tolibut

See also

References