Thiamine-triphosphatase

Thiamine-triphosphatase is an enzyme involved in thiamine metabolism. It catalyzes the chemical reaction

thiamin triphosphatase
Identifiers
EC no.	3.6.1.28
CAS no.	9068-47-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

thiamine triphosphatase
Identifiers
Symbol	THTPA
NCBI gene	79178
HGNC	18987
RefSeq	NM_024328
UniProt	Q9BU02
Other data
EC number	3.6.1.28
Locus	Chr. 14 q11.2
Search for Structures Swiss-model Domains InterPro

thiamine triphosphate + H₂O $\rightleftharpoons$ thiamine diphosphate + phosphate

This enzyme belongs to the family of acid anhydride hydrolases, specifically those acting on phosphorus-containing anhydrides. Its systematic name is thiamine triphosphate phosphohydrolase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JMU.

See also

• Thiamine-diphosphate kinase

References

• Hashitani Y, Cooper JR (1972). "The partial purification of thiamine triphosphatase from rat brain". J. Biol. Chem. 247 (7): 2117–9. doi:10.1016/S0021-9258(19)45498-7. PMID 4335862.