Template:Side effects of cyproterone acetate in the SExual-HOrmonal Surveillance STudy (SEHOST)
Side effect | Males (136 mg/day)[a] (n = 1248) (%) |
Females (18 mg/day)[a] (n = 1258) (%) |
Total (77 mg/day)[a] (n = 2506) (%) |
---|---|---|---|
Elevated liver enzymes[b] | 12.5 | 3.6 | 9.6 |
Gynecomastia, breast pain | 4.9 | 1.0 | 2.9 |
Overweightness, weight gain | 0.9 | 4.1 | 2.5 |
Headache, migraine | – | 3.4 | 1.7 |
Depression, anxiety, nightmares, mood swings | 1.0 | 1.8 | 1.4 |
Gastrointestinal dysfunction | 0.2 | 2.3 | 1.2 |
Thyroid dysfunction | 0.2 | 1.8 | 1.0 |
Skin changes (pigmentation, chloasma, others) | 0.3 | 1.4 | 0.8 |
Edema | – | 1.1 | 0.6 |
Adrenal insufficiency or hyperplasia | 0.2 | 0.8 | 0.5 |
Tiredness, lethargy, apathy | 0.6 | 0.6 | 0.6 |
Alopecia, hair growth | 0.2 | 0.2 | 0.2 |
Increased asthma attack rates | – | 0.3 | 0.2 |
Osteoporosis | 0.2 | 0.08 | 0.2 |
More frequently prone to attacks | 0.2 | 0.2 | 0.2 |
Diabetes mellitus | 0.08 | 0.08 | 0.08 |
Total (excluding elevated liver enzymes) | 9.0 | 19.1 | 14.0 |
Notes: Data from the SExual-HOrmonal Surveillance STudy (SEHOST), a long-term pharmacoepidemiologic active surveillance study. The sample included males and females age 3 to 75 years with precocious puberty, hyperandrogenism, sexual deviance, and/or transgenderism; prostate cancer was not included. Sources: [1][2] |
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Usage
This template can be used to easily insert a table detailing the side effects of cyproterone acetate in the SExual-HOrmonal Surveillance STudy (SEHOST) into an article. It comes with two pre-provided references.
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Notes and references
- ^ Heinemann LA, Will-Shahab L, van Kesteren P, Gooren LJ (May 1997). "Safety of cyproterone acetate: report of active surveillance". Pharmacoepidemiol Drug Saf. 6 (3): 169–78. doi:10.1002/(SICI)1099-1557(199705)6:3<169::AID-PDS263>3.0.CO;2-3. PMID 15073785.
- ^ Rabe T, Feldmann K, Heinemann L, Runnebaum B (January 1996). "Cyproterone acetate: is it hepato- or genotoxic?". Drug Saf. 14 (1): 25–38. doi:10.2165/00002018-199614010-00004. PMID 8713486.
- ^ a b c Average dosage; range less than 10 mg/day to >200 mg/day.
- ^ Liver enzymes monitored in 1,685 individuals, including 1,131 males and 554 females.