Telmisartan/amlodipine, sold under the brand name Twynsta among others, is a fixed-dose combination medication used to treat high blood pressure.[2] It is a combination of telmisartan, an angiotensin II receptor antagonist, and amlodipine, as the besilate, a calcium channel blocker.[2] It is taken by mouth.[2]
| Combination of | |
|---|---|
| Telmisartan | Angiotensin II receptor antagonist |
| Amlodipine | Calcium channel blocker |
| Clinical data | |
| Trade names | Twynsta, others |
| License data | |
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| KEGG | |
Common side effects include dizziness, swelling, and back pain.[2] Severe side effects may include low blood pressure, kidney problems, electrolyte problems, and a heart attack.[2] Use during pregnancy may harm the baby.[2] Telmisartan works by blocking the effects of angiotensin II while amlodipine works by decreasing calcium ion entry into smooth muscle and heart muscle.[2]
The combination was approved for medical use in the United States in 2009.[2] The combination is on the World Health Organization's List of Essential Medicines.[4][5] It is available as a generic medication.[6]
References
edit- ^ "Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
- ^ a b c d e f g h i "DailyMed - Telmisartan and Amlodipine tablet". DailyMed. Retrieved 30 October 2019.
- ^ "Twynsta (telmisartan/amlodipine) tablets, for oral use Initial U.S. Approval: 2009". DailyMed. Retrieved 18 March 2023.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
- ^ "Telmisartan and Amlodipine (Professional Patient Advice)". Drugs.com. Retrieved 30 October 2019.
