Talk:Trimethylolpropane phosphite

Strange, judging from the name for this compound I would draw a different structure V8rik 20:11, 29 August 2007 (UTC)

I got my structural info from this page on ChemFinder

Ben 20:55, 29 August 2007 (UTC)

The more common derivative, at least for inorganic chemists, is made from trimethylolethane, with a methyl not an ethyl. At least that is my experience. The review by the ligand's inventor seems to confirm this view: Verkade, J. G., "Ligation of trivalent phosphorus to protons, selenium and metals: some new aspects", Pure Appl. Chem., 1980, 52, 1131-9. doi:10.1351/pac198052041131. It is true that trimethylolpropane is far more important industrially than trimethylolethane though. So I was thinking of moving the article. We would keep the nice 3-d drawings since the core structure would be insensive to the alkyl substituent.--Smokefoot (talk) 17:51, 7 July 2009 (UTC)

We could just make a general article on caged phosphite esters, incorporating MeCage and EtCage, and possibly other rarer versions that do exist. I've got images for each of them.

Ben (talk) 22:03, 7 July 2009 (UTC)

Toxicity

Bicyclic phosphites and phosphates are VERY toxic! LD50 around 1 mg/kg and below. My literature gives 1,1 mg/kg for Trimethylolpropane phosphite and higher values for lower homologues. These compounds are no inhibitors AChE but seem to be inhibitors of GABA receptors, producing convulsions. --FK1954 (talk) 13:22, 16 July 2018 (UTC)

@FK1954: I have heard the same thing. Do you have any references to the LD50 and the mechanism?--Smokefoot (talk) 13:33, 16 July 2018 (UTC)

Hi Smokefoot now you can find the source in the article. It is a book from the 80ies, produced by scientists of the former GDR army. There are a lot of toxicity data about bicyclic phosphorus esters, phosphites, phosphates, and thiophosphates with different alkyl groups. Best wishes from Germany, Franz --FK1954 (talk) 13:51, 16 July 2018 (UTC)