Talk:Indoleamine 2,3-dioxygenase

EC wrong

This is, in fact, EC 1.13.11.52 not 42. --Ayacop (talk) 18:38, 31 December 2008 (UTC)

Should mention two isoforms inc IDO2

Should mention two isoforms and clarify if IDO2 from same or different gene. Also Epacadostat and BMS-986205 are selective inhibitors of IDO1 [1]. Indoximod inhibits IDO2. - Rod57 (talk) 31 August 2017‎

IDO is only active in a low-oxygen (hypoxic) environment.

"IDO is only active in a low-oxygen (hypoxic) environment." says [2] - Rod57 (talk) 19:43, 25 November 2017 (UTC)

Could expand IDO inhibitors for cancer

Discussion of mixed results of clinical trials in [3]. Ideally find a better source with refs. IDO inibitors could usefully be a separate article because of multiple enzymes targeted. - Rod57 (talk) 08:21, 7 June 2018 (UTC)

further reading

moving this here. this is excessive.

Further reading

• Grohmann U, Fallarino F, Puccetti P (May 2003). "Tolerance, DCs and tryptophan: much ado about IDO". Trends in Immunology. 24 (5): 242–8. doi:10.1016/S1471-4906(03)00072-3. PMID 12738417.
• Takikawa O (December 2005). "Biochemical and medical aspects of the indoleamine 2,3-dioxygenase-initiated L-tryptophan metabolism". Biochemical and Biophysical Research Communications. 338 (1): 12–9. doi:10.1016/j.bbrc.2005.09.032. PMID 16176799.
• Puccetti P (April 2007). "On watching the watchers: IDO and type I/II IFN". European Journal of Immunology. 37 (4): 876–9. doi:10.1002/eji.200737184. PMID 17393386.
• Kadoya A, Tone S, Maeda H, Minatogawa Y, Kido R (November 1992). "Gene structure of human indoleamine 2,3-dioxygenase". Biochemical and Biophysical Research Communications. 189 (1): 530–6. doi:10.1016/0006-291X(92)91590-M. PMID 1449503.
• Kamimura S, Eguchi K, Yonezawa M, Sekiba K (June 1991). "Localization and developmental change of indoleamine 2,3-dioxygenase activity in the human placenta". Acta Medica Okayama. 45 (3): 135–9. PMID 1716396.
• Tone S, Takikawa O, Habara-Ohkubo A, Kadoya A, Yoshida R, Kido R (January 1990). "Primary structure of human indoleamine 2,3-dioxygenase deduced from the nucleotide sequence of its cDNA". Nucleic Acids Research. 18 (2): 367. doi:10.1093/nar/18.2.367. PMC 330282. PMID 2326172.
• Werner-Felmayer G, Werner ER, Fuchs D, Hausen A, Reibnegger G, Wachter H (September 1989). "Tumour necrosis factor-alpha and lipopolysaccharide enhance interferon-induced tryptophan degradation and pteridine synthesis in human cells". Biological Chemistry Hoppe-Seyler. 370 (9): 1063–9. doi:10.1515/bchm3.1989.370.2.1063. PMID 2482041.
• Carlin JM, Borden EC, Byrne GI (June 1989). "Interferon-induced indoleamine 2,3-dioxygenase activity inhibits Chlamydia psittaci replication in human macrophages". Journal of Interferon Research. 9 (3): 329–37. doi:10.1089/jir.1989.9.329. PMID 2501398.
• Kobayashi K, Hayashi K, Sono M (September 1989). "Effects of tryptophan and pH on the kinetics of superoxide radical binding to indoleamine 2,3-dioxygenase studied by pulse radiolysis". The Journal of Biological Chemistry. 264 (26): 15280–3. PMID 2549057.
• Daley-Yates PT, Powell AP, Smith LL (November 1988). "Pulmonary indoleamine 2,3-dioxygenase activity and its significance in the response of rats, mice, and rabbits to oxidative stress". Toxicology and Applied Pharmacology. 96 (2): 222–32. doi:10.1016/0041-008X(88)90082-8. PMID 2848333.
• Burkin DJ, Kimbro KS, Barr BL, Jones C, Taylor MW, Gupta SL (July 1993). "Localization of the human indoleamine 2,3-dioxygenase (IDO) gene to the pericentromeric region of human chromosome 8". Genomics. 17 (1): 262–3. doi:10.1006/geno.1993.1319. PMID 8406467.
• Malina HZ, Martin XD (July 1996). "Indoleamine 2,3-dioxygenase: antioxidant enzyme in the human eye". Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. 234 (7): 457–62. doi:10.1007/BF02539413. PMID 8817290.
• Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B, Brown C, Mellor AL (August 1998). "Prevention of allogeneic fetal rejection by tryptophan catabolism". Science. 281 (5380): 1191–3. doi:10.1126/science.281.5380.1191. PMID 9712583.
• Takikawa O, Littlejohn TK, Truscott RJ (March 2001). "Indoleamine 2,3-dioxygenase in the human lens, the first enzyme in the synthesis of UV filters". Experimental Eye Research. 72 (3): 271–7. doi:10.1006/exer.2000.0951. PMID 11180976.
• Kudo Y, Boyd CA (March 2001). "The role of L-tryptophan transport in L-tryptophan degradation by indoleamine 2,3-dioxygenase in human placental explants". The Journal of Physiology. 531 (Pt 2): 417–23. doi:10.1111/j.1469-7793.2001.0417i.x. PMC 2278460. PMID 11230514.
• Papadopoulou ND, Mewies M, McLean KJ, Seward HE, Svistunenko DA, Munro AW, Raven EL (November 2005). "Redox and spectroscopic properties of human indoleamine 2,3-dioxygenase and a His303Ala variant: implications for catalysis". Biochemistry. 44 (43): 14318–28. doi:10.1021/bi0513958. PMID 16245948.
• Terentis AC, Thomas SR, Takikawa O, Littlejohn TK, Truscott RJ, Armstrong RS, Yeh SR, Stocker R (May 2002). "The heme environment of recombinant human indoleamine 2,3-dioxygenase. Structural properties and substrate-ligand interactions". The Journal of Biological Chemistry. 277 (18): 15788–94. doi:10.1074/jbc.M200457200. PMID 11867636.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Kvirkvelia N, Vojnovic I, Warner TD, Athie-Morales V, Free P, Rayment N, Chain BM, Rademacher TW, Lund T, Roitt IM, Delves PJ (February 2002). "Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells". Clinical and Experimental Immunology. 127 (2): 263–9. doi:10.1046/j.1365-2249.2002.01718.x. PMC 1906325. PMID 11876748.
• Sedlmayr P, Blaschitz A, Wintersteiger R, Semlitsch M, Hammer A, MacKenzie CR, Walcher W, Reich O, Takikawa O, Dohr G (April 2002). "Localization of indoleamine 2,3-dioxygenase in human female reproductive organs and the placenta". Molecular Human Reproduction. 8 (4): 385–91. doi:10.1093/molehr/8.4.385. PMID 11912287.
• Basran J, Efimov I, Chauhan N, Thackray SJ, Krupa JL, Eaton G, Griffith GA, Mowat CG, Handa S, Raven EL (October 2011). "The mechanism of formation of N-formylkynurenine by heme dioxygenases". Journal of the American Chemical Society. 133 (40): 16251–7. doi:10.1021/ja207066z. PMC 3210546. PMID 21892828.

-- Jytdog (talk) 02:12, 10 October 2018 (UTC)