Talk:Hepatic encephalopathy/GA1

GA Review

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Reviewer: Okay, I will start reviewing here and do some copyediting as I go. Please revert any changes I inadvertently make to meaning. Hopefully I will try to give it a bit of a shove to FAC. I will jot queries below. Cheers, Casliber (talk · contribs) 09:24, 10 April 2010 (UTC)

portosystemic encephalopathy - is this name common? I don't recall hearing this name used but then again, alot of my below-head medicine is rusty... :/ But needs to go in body of text somewhere..

In the Signs and symptoms section where it says (flapping) tremor - I'd go a bit more and say a characteristic flapping tremor (known as hepatic flap).

Other waste products implicated in hepatic encephalopathy include mercaptans (substances containing a thiol group), short-chain fatty acids and phenol - how do phenol and come into the picture here?

The prevalence of minimal hepatic encephalopathy detectable on formal neuropsychological testing is 60–80%; this increases the likelihood of developing overt encephalopathy in the future. - interesting, but makes me think that some might have previous alcohol-related brain damage. Do any sources discuss differentiating these?

Otherwise lookin' good. Casliber (talk · contribs) 00:34, 11 April 2010 (UTC)

Thanks Casliber, and thanks too for fixing my grammar and other mistakes.

The name "portosystemic encephalopathy" is mainly used in older publications (e.g. Sherlock 1954) but there is still current use, e.g. by the Germans who described the PSE-Syndrom-test.

I have taken your advice on the "liver flap".

The mention of phenol and SCFAs is only because I wanted to discuss other players rather than just ammonia, and the Harrisson's source mentioned them. I'll happily take them out if you think that is better because there is really very little discussion on these in any of the other sources.

Truthfully, the sources make little attempt to distinguish MHE from alcoholic encephalopathies, Wernicke's and so on. If you are aware of anything, please let me know! JFW | T@lk 01:01, 11 April 2010 (UTC)

(1) No no, mentioning them is good - I was wondering how/where they come from (i..e unwelcome metabolites from where?) (2) Given that technically everything in the lead should be in the body of the text, then mentioning portosystemic encephalopathy as an older (but also current) term should appear, maybe in the history section, or if you are keen, a small etymology section at the top. (3) will maybe look up to see if there is anything distinguishing ARBD from mild encephalogpathy. Casliber (talk · contribs) 02:45, 11 April 2010 (UTC)

Will work the terminology into the article body. The Harrison's source doesn't say where the other substances come from. JFW | T@lk 23:49, 12 April 2010 (UTC)

Okay, if they can't be sourced they can't be sourced then. Don't worry too much about them. Casliber (talk · contribs) 01:29, 13 April 2010 (UTC)

May as well haul out the green '+' icons then...

1. Well written?:

Prose quality:

Manual of Style compliance:

2. Factually accurate and verifiable?:

References to sources:

Citations to reliable sources, where required:

No original research:

3. Broad in coverage?:

Major aspects:

Focused:

4. Reflects a neutral point of view?:

Fair representation without bias:

5. Reasonably stable?

No edit wars, etc. (Vandalism does not count against GA):

6. Illustrated by images, when possible and appropriate?:

Images are copyright tagged, and non-free images have fair use rationales:

Images are provided where possible and appropriate, with suitable captions:

• Images need WP:ALT text but not a deal-breaker....

Overall:

Pass or Fail: i.e. I think we're over the GA line here/congrats (again)  :) Casliber (talk · contribs) 06:32, 13 April 2010 (UTC)

Thanks much! JFW | T@lk 21:23, 14 April 2010 (UTC)

Warfarin

In addition to BNZs, oral anticoagulants such as coumarins (warfarin) may also cause hepatic encephalopathy. —Preceding unsigned comment added by 92.28.33.151 (talk) 16:29, 9 May 2010 (UTC)

And the evidence for your claim is... JFW | T@lk 20:37, 14 July 2010 (UTC)