Talk:Hedgehog signaling pathway

Untitled

Excellent, I didnt realize someone had made a page about the molecule already (Sonic hedgehog) because there were no links to it. This page should be deleted; failure to realize page already existed attributed to lack of organization on Wikipedia, as links to the previously created page were absent. Note to future contributers: add links to your page on related pages!!!MrPMonday 07:49, 15 May 2006 (UTC)

Expansion

This page should be devoted to the hedgehog signaling pathway. Sonic hedgehog as a protein has its own page. This is they way I think it would be best to structure the article:

• Intro
• Discovery
• In Drosophila
  • Function - role in development
  • Mechanism - Hedgehog signaling in fruitflies
• In mammals
  • Function - development, stem cells
  • Mechanism (I can add some infromation about smo ptch regulations and also i think it might be time to add some info about cilia)
  • Human disease - mutations in HH pathway lead to holoprosencephaly, disregulation to cancer, advances in drug design go here (I can comment on this in more detail and maybe create a few diagrams)
• Evolution - this is not crucial but would be nice, contrast fly and mammals here, mention zebrafish, hypotheses of when the pathway evolved (AFAIK it's not present in c. elegans, The function and expansion of the Patched- and Hedgehog-related homologs in C. elegans), relationship to Wnt.

Peter Z.^Talk 14:16, 22 June 2006 (UTC)

References A few papers I would like to incorporate into the article... This list will be extended.

• Rahnama F, Shimokawa T, Lauth M, Finta C, Kogerman P, Teglund S, Toftgard R and Zaphiropoulos PG (2006). "Inhibition of GLI1 gene activation by Patched1". Biochem J. 394 (Pt 1): 19–26. doi:10.1042/BJ20050941. PMC 1385998. PMID 16229683.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Jeong J and McMahon AP (2005). "Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1". Development. 132 (1): 143–154. doi:10.1242/dev.01566. PMID 15576403.
• Harfe BD, Scherz PJ, Nissim S, Tian H, McMahon AP and Tabin CJ (2004). "Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities". Cell. 118 (4): 517–528. doi:10.1016/j.cell.2004.07.024. PMID 15315763.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Tian H, Jeong J, Harfe BD, Tabin CJ and McMahon AP (2005). "Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand". Development. 132 (1): 133–142. doi:10.1242/dev.01563. PMID 15576405.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• This article - [1] and this table in particular [2]. There's a wealth of meterial there, any help sorting through for notable examples would be very welcome.

Peter Z.^Talk 21:35, 23 June 2006 (UTC)

• SHH rapidly evolved during recent human evolution, perhaps contributing to the increase in brain size and complexity - PMID 15620360 --Peter Z.^Talk 20:51, 25 June 2006 (UTC)

John, just to let you know - I am adapting a figure on evolution of hedgehog ligands. Peter Z.^Talk 18:45, 28 June 2006 (UTC)

This article is indeed a fine example of how the articles should look. Fabuluous work. -- Boris 23:54, 29 June 2006 (UTC)

The images themselves are great, but I see Image:HedgehogCiR.png crowding Image:Wingless.png to the right and compressing the text. But this is at 1920x1200, which isn't the most common resolution - has anyone else noticed a problem? Opabinia regalis 02:18, 30 June 2006 (UTC)

I've made a slight change to the placement of images... It seems to work fine on 1400x1050 and lower. If you still have the same problem, would you mind emailing me a screenshot to oook dot pz at gmail dot com? --Peter Z.^Talk 08:50, 30 June 2006 (UTC)

I still see an overlap at this resolution - screenshot sent. Opabinia regalis 01:44, 1 July 2006 (UTC)

Is...?

Yeah. Um. Under "Fruit Fly" and the Sub-Heading "Roles," is the word "Frizzled" at the end of the first sentence of the third paragraph supposed to be there? Just wondering. --Heero Kirashami (talk) 20:05, 31 December 2007 (UTC)

Yeah it's supposed to be there. "Frizzled" is the name of the receptor protein. Genetics is full of funny names for things. --NicmaLauren09:01, 04 August 2009

New Diagram and new research

I have replaced two confusing diagrams with a new SVG version. Please comment, fact check, approve/disapprove, etc. I may tinker with the formatting a bit seeing as Wikipedia's SVG rendering engine dislikes my fonts and sucks for the most part.

I am a microbiologist, not a cell biologist but I got interested in this pathway because of an article published today in PLoS Biology about the possibility that the Hh->Ptch1->Smo pathway evolved from bacterial lipid homeostasis mechanisms. I think it would be great work to encorporate into this article. I feel I am not qualified to filter this new work into the preexisting article, maybe someone else can?

Hausmann G, von Mering C, Basler K, 2009 The Hedgehog Signaling Pathway: Where Did It Come From?. PLoS Biol 7(6): e1000146. doi:10.1371/journal.pbio.1000146

Adenosine^talk 21:15, 30 June 2009 (UTC)

Pathway picture is unhelpful

The overview pathway diagram should really be removed, or the hedgehog pathway be highlighted. The hedgehog signalling pathway is only a small part of it and is not correct. The pathway diagrams lower down ar more correct. This is only going to confuse readers and not help them. Alexbateman (talk) 09:21, 9 July 2010 (UTC)

 Done Boghog (talk) 06:32, 15 July 2010 (UTC)

This can be used as a better pathway picture. Foxboyprower (talk) 17:10, 19 February 2013 (UTC)

"Sonic hedgehog" - Trolling?

I serious thought someone was trolling real hard. But this is its true name... no jokes! 129.180.171.90 (talk) 06:20, 23 May 2014 (UTC)

Drug target

For myeloid malignancies doi:10.1111/bjh.13426 JFW | T@lk 12:04, 23 April 2015 (UTC)

Assessment comment

The comment(s) below were originally left at Talk:Hedgehog signaling pathway/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

This article seems pretty good, but I think needs a bit of de-jargoning to progress to GA standard Ciar 05:23, 14 April 2007 (UTC) This article is very good as it is, but of course some improvements could be made. Especially in the mechanism sections, more organization of information (i.e. an ordered and/or bullet list of involved process) could assist more layman readers in understanding it. This can be added as a very helpful visual aid. Foxboyprower (talk) 17:07, 19 February 2013 (UTC)

Last edited at 17:07, 19 February 2013 (UTC). Substituted at 17:32, 29 April 2016 (UTC)

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